Y-site physical compatibility of hydrocortisone continuous infusions with admixtures used in critically ill patients.

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Jaime A FousheeAlyson G Wilder

Abstract

Critically ill patients with septic shock often receive multiple intravenous medications, necessitating either the placement of separate lines for medication administration or administration of medications concurrently through a Y-site connector only where compatibility has been demonstrated. The purpose of this study was to examine the physical compatibility of hydrocortisone infusions and select intravenous medications through a simulated Y site. The medications tested for simulated Y-site physical compatibility with hydrocortisone included acetaminophen, albumin, cefepime, ciprofloxacin, cisatracurium, doripenem, epinephrine, esomeprazole, ibuprofen, levofloxacin, levothyroxine, meropenem, and norepinephrine. Hydrocortisone in solution with 0.9% sodium chloride injection was combined with an equivalent volume of solutions of each test drug at maximum or commercially available concentrations used clinically in intensive care units, as appropriate. The samples were evaluated using turbidimetric measurements and examined visually against light and dark backgrounds to determine physical compatibility. Observations and analyses were completed over a one-hour period at 15-minute intervals beginning immediately after mixing. Each t...Continue Reading

References

Mar 4, 2000·JAMA : the Journal of the American Medical Association·D AnnaneE Bellissant
Aug 21, 2002·JAMA : the Journal of the American Medical Association·Djillali AnnaneEric Bellissant
Mar 21, 2003·The New England Journal of Medicine·David C McGee, Michael K Gould
Feb 20, 2007·Critical Care : the Official Journal of the Critical Care Forum·Pekka LoisaEsko Ruokonen
Feb 28, 2007·Intensive Care Medicine·Steffen Weber-CarstensDidier Keh
Jan 11, 2008·The New England Journal of Medicine·Charles L SprungUNKNOWN CORTICUS Study Group
Jan 20, 2017·Intensive Care Medicine·Andrew RhodesR Phillip Dellinger
Jan 20, 2018·The New England Journal of Medicine·Balasubramanian VenkateshUNKNOWN ADRENAL Trial Investigators and the Australian–New Zealand Intensive Care Society Clinical Trials Group
Mar 1, 2018·The New England Journal of Medicine·Djillali AnnaneUNKNOWN CRICS-TRIGGERSEP Network
Aug 15, 2018·Frontiers in Immunology·Nicholas HemingDjillali Annane

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