Y-STR diversity in the Himalayas.

International Journal of Legal Medicine
Tenzin GaydenRene J Herrera

Abstract

Linguistic and ethnic diversity throughout the Himalayas suggests that this mountain range played an important role in shaping the genetic landscapes of the region. Previous Y-chromosome work revealed that the Himalayas acted as a biased bidirectional barrier to gene flow across the cordillera. In the present study, 17 Y-chromosomal short tandem repeat (Y-STR) loci included in the AmpFlSTR® Yfiler kit were analyzed in 344 unrelated males from three Nepalese populations (Tamang, Newar, and Kathmandu) and a general collection from Tibet. The latter displays the highest haplotype diversity (0.9990) followed by Kathmandu (0.9977), Newar (0.9570), and Tamang (0.9545). The overall haplotype diversity for the Himalayan populations at 17 Y-STR loci was 0.9973, and the corresponding values for the extended (11 loci) and minimal (nine loci) haplotypes were 0.9955 and 0.9942, respectively. No Y-STR profiles are shared across the four Himalayan collections at the 17-, 11-, and nine-locus resolutions considered, indicating a lack of recent gene flow among them. Phylogenetic analyses support our previous findings that Kathmandu, and to some extent Newar, received significant genetic influence from India while Tamang and Tibet exhibit limited...Continue Reading

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Citations

Jul 24, 2012·Forensic Science International. Genetics·Myung Jin ParkKyoung-Jin Shin
Oct 19, 2011·Forensic Science International. Genetics·Tenzin GaydenRene J Herrera
Jan 18, 2011·Legal Medicine·Harlette LacauRene J Herrera
Jul 29, 2015·Forensic Science International. Genetics·Tianzhen GaoYiping Hou
Nov 28, 2012·Gene·Tanya M SimmsRene J Herrera
May 27, 2011·Forensic Science International. Genetics·Kaye N BallantyneManfred Kayser
Aug 9, 2016·Legal Medicine·David Perez-BenedicoRene J Herrera
Jan 21, 2017·BMC Genomics·Amy M ColeGianpiero L Cavalleri

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