Y1 -receptor-ligand-functionalized ultrasmall upconversion nanoparticles for tumor-targeted trimodality imaging and photodynamic therapy with low toxicity

Nanoscale
Zhangsen YuAiguo Wu

Abstract

Achieving efficient photodynamic therapy (PDT) in deeper biological tissue is still the biggest bottleneck that limits its widespread application in clinic. Although deeper biological tissue PDT could be realized through a combination of upconversion nanoparticles with a photosensitizer, issues with particle-size-induced upconversion fluorescence (UF) reduction and the related in vivo toxicity still cannot be solved properly. In this study, we synthesized Y1Rs-ligand [Pro30, Nle31, Bpa32, Leu34]NPY(28-36) (NPY)-modified and photosensitizer MC540-loaded LiLuF4:Yb,Er@nLiGdF4@mSiO2 multifunctional nanocomposites (MNPs) with a core-multishell structure and ultrasmall size. Their in vitro and in vivo breast tumor targeting, trimodality imaging performance, PDT therapeutic efficacy, and acute toxicity were evaluated. Our results demonstrated that the core-multishell MNPs(MC540) could achieve excellent UF imaging, and that doping with Gd3+ and Lu3+ rare earth ions could enhance the MR and CT imaging performance. In addition, the mSiO2 shell provided a higher loading rate for the photosensitizer MC540, and the DSPE-PEG thin layer coating outside the MNPs(MC540) further improved the water solubility and biocompatibility, reducing the ac...Continue Reading

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Citations

Jan 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lili XuChunxia Li
Apr 4, 2019·Chemical Communications : Chem Comm·Xiaoxia WuFu Wang
Jul 1, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Miao FengRuichan Lv
Sep 3, 2019·The Journal of Toxicological Sciences·Yuan ChenZhangsen Yu
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Na RenXin Yu
Jan 23, 2021·Inorganic Chemistry·Ling-Gui LiuHai-Yang Liu
May 26, 2021·Journal of Colloid and Interface Science·Yuehong ZhangYong Zhang
Aug 10, 2021·Advanced Drug Delivery Reviews·Melgious Jin Yan AngXiaogang Liu
Aug 24, 2021·Frontiers in Endocrinology·Shu-Ting LinSi-Qing Cai

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Methods Mentioned

BETA
X-ray
MDA
ELISA

Software Mentioned

GraphPad
GraphPad Prism
SIEMENS CT

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