PMID: 9556029Apr 29, 1998Paper

Y1 receptors in the nucleus accumbens: ultrastructural localization and association with neuropeptide Y

Journal of Neuroscience Research
V M PickelH A Weiland

Abstract

Neuropeptide Y (NPY) is present in aspiny neurons in the nucleus accumbens (NAc), which also contains moderate levels of ligand binding and mRNA for the Y1 receptor. To determine the potential functional sites for receptor activation, we examined the electron microscopic immunocytochemical localization of antipeptide antisera against the Y1 receptor in the rat NAc. We also combined immunogold and immunoperoxidase labeling to show that, in this region, Y1 receptors are present in certain somatodendritic and axonal profiles that contain NPY or that appose NPY containing neurons. The Y1-like immunoreactivity (Y1-LI) was seen occasionally along plasma membranes but was associated more commonly with smooth endoplasmic reticulum (SER) and tubulovesicular organelles in somata and dendrites of spiny and aspiny neurons. The mean density of immunoreactive dendrites and spines per unit volume was greater in the "motor-associated" core than in the shell of the NAc. Y1-LI was also seen in morphologically heterogenous axon terminals, including those forming asymmetric excitatory-type synapses, and in selective astrocytic processes near this type of junction. We conclude that Y1 receptors play a role in autoregulation of NPY-containing neuron...Continue Reading

Citations

Jul 13, 2002·The Journal of Comparative Neurology·Hideki MatsudaTomas Hökfelt
Jan 16, 2007·Trends in Pharmacological Sciences·Pablo BrumovskyTomas Hökfelt
Aug 12, 2014·Biological Psychiatry·José K van den HeuvelSusanne E la Fleur
Jan 15, 2015·Neuroscience·S Liu, S L Borgland
May 2, 2016·Physiology & Behavior·Myrtille C R GumbsSusanne E la Fleur
Aug 6, 2003·The Journal of Comparative Neurology·Michael L WolakJanice H Urban
Mar 1, 2002·Experimental Neurology·Pablo R BrumovskyTomas Hökfelt
Jul 25, 2021·International Journal of Molecular Sciences·Masaki TanakaYoshihisa Watanabe

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