Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue

The Journal of General Virology
Pilar NajarroGeoffrey L Smith

Abstract

Yaba-like disease virus (YLDV) gene 7L encodes a seven-transmembrane G protein-coupled receptor with 53 % amino acid identity to human CC chemokine receptor 8 (CCR8). Initial characterization of 7L showed that this 56 kDa cell-surface glycoprotein binds human CCL1 with high affinity (Kd=0.6 nM) and induces signal transduction by activation of heterotrimeric G proteins and downstream protein kinases. Further characterization of YLDV 7L is presented here and shows that murine CC chemokines can induce G-protein activation via the 7L receptor, despite having a low binding affinity for this receptor. In addition, when expressed by recombinant vaccinia virus (VACV), YLDV 7L was found on the outer envelope of VACV extracellular enveloped virus. The contribution of 7L to poxvirus pathogenesis was investigated by infection of mice with a recombinant VACV expressing 7L (vDeltaB8R-7L) and was compared with the outcome of infection by parental and revertant control viruses. In both intranasal and intradermal models, expression of 7L caused attenuation of VACV. The role of this protein in viral virulence is discussed.

References

Jun 1, 1990·Journal of Virology·F G Falkner, B Moss
Sep 1, 1989·Virology·J C KnightJ J Esposito
Jul 7, 1997·The Journal of Experimental Medicine·H L TiffanyP M Murphy
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·A VanderplasschenG L Smith
Jul 21, 1999·Viral Immunology·A M BennettR W Titball
Nov 26, 1999·The Journal of General Virology·D C Tscharke, G L Smith
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L KremerG Márquez
Jul 19, 2002·The Journal of General Virology·Julian A SymonsGeoffrey L Smith
Jul 19, 2002·The Journal of General Virology·David C TscharkeGeoffrey L Smith
Sep 19, 2002·The Journal of General Virology·Oliver KraussGeoffrey L Smith
Oct 17, 2002·Naunyn-Schmiedeberg's Archives of Pharmacology·Roland Seifert, Katharina Wenzel-Seifert
Dec 6, 2002·The Journal of General Virology·Geoffrey L SmithMansun Law
Jan 4, 2003·Nature Reviews. Immunology·Antonio Alcami
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrick C ReadingGeoffrey L Smith
Dec 3, 2003·The Journal of General Virology·Pilar NajarroGeoffrey L Smith
Jan 23, 2004·The Journal of Biological Chemistry·Julio GutiérrezGabriel Márquez
May 5, 2004·The Journal of Experimental Medicine·Patrick SchaerliBernhard Moser
May 29, 2004·The Journal of General Virology·Nathan W BartlettGeoffrey L Smith
Oct 14, 2004·Annals of the Rheumatic Diseases·B Moser, K Willimann
Nov 10, 2004·The Journal of Experimental Medicine·Chunfeng QuGwendalyn J Randolph
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael GombertBernhard Homey

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