Yam (Dioscorea batatas) Root and Bark Extracts Stimulate Osteoblast Mineralization by Increasing Ca and P Accumulation and Alkaline Phosphatase Activity

Preventive Nutrition and Food Science
Suji KimIn-Sook Kwun

Abstract

Yam (Dioscorea batatas) is widely consumed as functional food for health promotion mainly in East Asia countries. We assessed whether yam root (tuber) or bark (peel) extracts stimulated the activity of osteoblasts for osteogenesis. MC3T3-E1 cells (mouse osteoblasts) were treated with yam root extracts (water or methanol) (study I) or bark extracts (water or hexane) (study II) within 0~10 μg/mL during the periods of osteoblast proliferation (5~10 day), matrix maturation (11~15 day) and mineralization (16~20 day) as appropriate. In study I, both yam root water and methanol extracts increased cell proliferation as concentration-dependent manner. Cellular collagen synthesis and alkaline phosphatase (ALP) activity, both the indicators of bone matrix protein and inorganic phosphate production for calcification respectively, were also increased by yam root water and methanol extract. Osteoblast calcification as cell matrix Ca and P accumulation was also increased by the addition of yam root extracts. In study II, yam bark extracts (water and hexane) increased osteoblast proliferation and differentiation, as collagen synthesis and ALP activity and osteoblast matrix Ca and P deposition. The study results suggested that both yam root and...Continue Reading

References

Oct 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G S SteinT A Owen
Jun 3, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D WangR T Franceschi
Jul 11, 2002·Oral Diseases·T Katagiri, N Takahashi
Oct 16, 2003·Journal of Agricultural and Food Chemistry·Deng-Jye YangLucy Sun Hwang
Aug 10, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Meihua JinHyeun Wook Chang
Mar 20, 2012·Journal of Medicinal Food·Soyoung KimTaesun Park
Dec 28, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Pham Thi Thu HuongYoung Jin Jeon
Jul 12, 2013·Journal of Agricultural and Food Chemistry·Yen-Hung YehYa-Ting Lee

Citations

Mar 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chun-Tao CheChristopher Wai Kei Lam

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