Abstract
Yangjing capsule (YC), a traditional Chinese compound herbal preparation, has been proven as an effective drug to improve spermatogenesis in clinical practice. However, its pharmacological mechanisms were not fully clarified. This study was designed to investigate the protective effects of YC on spermatogenesis in the mouse model of spermatogenesis dysfunction induced by cyclophosphamide (CP). The administration of YC significantly increased the epididymal index, sperm count, and sperm motility of model mice. Histopathological changes demonstrated that CP caused obvious structural damage to testis, which were reversed by the administration of YC. Results from TUNEL assay showed that treatment with YC dramatically decreased the apoptosis of spermatogenic cell induced by CP. Moreover, YC treatment could inhibit the mRNA and protein expression of Bax to Bcl-2 and also raised expression of AR at both mRNA and protein levels. These data suggest that YC might ameliorate spermatogenesis in male mice exposed to CP through inhibiting the apoptosis of spermatogenic cell and enhancing the actions of testosterone in spermatogenesis.
References
Aug 1, 1995·Mutation Research·D AndersonP B Selby
Oct 1, 1996·Biology of Reproduction·L O'DonnellD M Robertson
Jun 1, 1997·Biology of Reproduction·L CaiB Robaire
Mar 2, 1999·Reviews of Reproduction·A P Sinha Hikim, R S Swerdloff
Mar 22, 2002·Biology of Reproduction·Lonnie D RussellC Michael Knudson
Jul 18, 2002·Journal of Asian Natural Products Research·Hui-Ming HuaYue-Hu Pei
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shuyuan YehMin-Chi Hung
Jan 1, 2004·Development·Robert W Holdcraft, Robert E Braun
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Karel De GendtGuido Verhoeven
Apr 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chawnshang ChangShuyuan Yeh
Mar 7, 2006·Toxicology·Namasivayam ElangovanSin-Tak Chu
Jul 13, 2007·Reproductive Toxicology·Myung Sook OhSeong Kyu Park
Jan 28, 2010·Fertility and Sterility·Katherine L O'Flynn O'BrienAshok Agarwal
Apr 1, 2010·Reproduction, Fertility, and Development·Gaffari TürkAhmet Ateşşahin
Dec 16, 2010·Journal of Cellular and Molecular Medicine·Shree Ram SinghSteven X Hou
Sep 29, 2011·International Journal of Andrology·E VicariS La Vignera
Dec 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Dalin SunChao Gao
Mar 16, 2013·Phytotherapy Research : PTR·Ding YuanChangcheng Zhang
Sep 10, 2013·The Journal of Clinical Endocrinology and Metabolism·Bradley D Anawalt
Jan 8, 2014·Laboratory animal research·Sung-Hwan KimJong-Choon Kim
Mar 7, 2014·Seminars in Cell & Developmental Biology·Kin Lam FokHsiao Chang Chan
Mar 7, 2014·Seminars in Cell & Developmental Biology·Lee B Smith, William H Walker
May 13, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Zhiqiang WangChao Gao
Citations
Jul 30, 2020·Scientific Reports·Maha I AlkhalafNouf A Babteen
May 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Baofang JinPing Wu
Feb 10, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Gabriel O OludareGanbotei G Semidara
May 28, 2021·Drug Design, Development and Therapy·Xue BaiZhenquan Liu