YAP and TAZ Regulate Cc2d1b and Purβ in Schwann Cells

Frontiers in Molecular Neuroscience
Belin SophiePoitelon Yannick

Abstract

Schwann cells (SCs) are exquisitely sensitive to the elasticity of their environment and their differentiation and capacity to myelinate depend on the transduction of mechanical stimuli by YAP and TAZ. YAP/TAZ, in concert with other transcription factors, regulate several pathways including lipid and sterol biosynthesis as well as extracellular matrix receptor expressions such as integrins and G-proteins. Yet, the characterization of the signaling downstream YAP/TAZ in SCs is incomplete. Myelin sheath production by SC coincides with rapid up-regulation of numerous transcription factors. Here, we show that ablation of YAP/TAZ alters the expression of transcription regulators known to regulate SC myelin gene transcription and differentiation. Furthermore, we link YAP/TAZ to two DNA binding proteins, Cc2d1b and Purβ, which have no described roles in myelinating glial cells. We demonstrate that silencing of either Cc2d1b or Purβ limits the formation of myelin segments. These data provide a deeper insight into the myelin gene transcriptional network and the role of YAP/TAZ in myelinating glial cells.

References

Jan 24, 2004·Developmental Biology·Hideki YamaguchiMing-Jer Tsai
Mar 27, 2004·Science·Galin V MichailovKlaus-Armin Nave
Jun 17, 2005·Journal of the Peripheral Nervous System : JPNS·Maria Laura Feltri, Lawrence Wrabetz
Sep 1, 2005·Neuron·Carla TaveggiaJames L Salzer
Nov 7, 2006·Developmental Cell·Ciara M Gallagher, Juergen A Knoblich
Nov 8, 2006·Current Biology : CB·Jennifer L ChildressGeorg Halder
Feb 13, 2008·Journal of Neurochemistry·Anna DobretsovaPatricia A Wight
May 9, 2009·Biological Psychiatry·Mahmoud R HadjighassemPaul R Albert
Jun 16, 2009·Nature Neuroscience·Ashwin WoodhooKristján R Jessen
Dec 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mark H G VerheijenAugust B Smit
Mar 3, 2010·The Journal of Biological Chemistry·Richard W TsikaJuan Ji
Nov 4, 2010·Journal of Neurochemistry·Sung-Wook JangJohn Svaren
Dec 16, 2010·The European Journal of Neuroscience·Mahmoud R HadjighassemPaul R Albert
Jun 10, 2011·Nature·Sirio DupontStefano Piccolo
Jul 7, 2011·Nucleic Acids Research·Debra L FultonAlan C Peterson
Feb 15, 2012·Neuromolecular Medicine·Yannick PoitelonValérie Delague
Sep 29, 2012·Journal of Cellular Physiology·Edward M JohnsonJennifer Gordon
Dec 24, 2013·Nature Cell Biology·Morvarid MohseniFernando D Camargo
Aug 16, 2014·Current Biology : CB·Veronica A CodeliaKenneth D Irvine
Sep 5, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ye ZhangJian Qian Wu
Oct 18, 2014·Science·Ian A McKenzieWilliam D Richardson
Jan 24, 2015·The Journal of Biological Chemistry·Holly A HungJohn Svaren
Apr 30, 2015·Glia·Kelly R MonkCarla Taveggia
May 15, 2015·Glia·Camila Lopez-AnidoJohn Svaren
Jun 5, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ki H MaJohn Svaren
Jul 29, 2015·The Journal of Cell Biology·Nam-Gyun Kim, Barry M Gumbiner

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Citations

Feb 12, 2021·Frontiers in Molecular Neuroscience·Anjali BalakrishnanCarol Schuurmans
Jun 3, 2021·International Journal of Molecular Sciences·Zhenyuan XuGreg M Harris

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Datasets Mentioned

BETA
GSE79115

Methods Mentioned

BETA
RNA-seq
Infection
PCR
RNAseq

Software Mentioned

ARRIVE
ImageJ

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