Yarrowia lipolytica Pex20p, Saccharomyces cerevisiae Pex18p/Pex21p and mammalian Pex5pL fulfil a common function in the early steps of the peroxisomal PTS2 import pathway

EMBO Reports
Henrik EinwächterW Schliebs

Abstract

Import of peroxisomal matrix proteins is essential for peroxisome biogenesis. Genetic and biochemical studies using a variety of different model systems have led to the discovery of 23 PEX genes required for this process. Although it is generally believed that, in contrast to mitochondria and chloroplasts, translocation of proteins into peroxisomes involves a receptor cycle, there are reported differences of an evolutionary conservation of this cycle either with respect to the components or the steps involved in different organisms. We show here that the early steps of protein import into peroxisomes exhibit a greater similarity than was thought previously to be the case. Pex20p of Yarrowia lipolytica, Pex18p and Pex21p of Saccharomyces cerevisiae and mammalian Pex5pL fulfil a common function in the PTS2 pathway of their respective organisms. These non-orthologous proteins possess a conserved sequence region that most likely represents a common PTS2-receptor binding site and di-aromatic pentapeptide motifs that could be involved in binding of the putative docking proteins. We propose that not necessarily the same proteins but functional modules of them are conserved in the early steps of peroxisomal protein import.

References

Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·P M Chevray, D Nathans
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R ErdmannW H Kunau
Jul 1, 1996·Nucleic Acids Research·U GüldenerJ H Hegemann
Oct 1, 1996·The Journal of Cell Biology·R Erdmann, G Blobel
Oct 6, 1997·The EMBO Journal·C BrocardA Hartig
May 20, 1998·Current Biology : CB·W H Kunau, R Erdmann
Aug 31, 2000·Annual Review of Biochemistry·S SubramaniW B Snyder
Oct 24, 2000·The Journal of Biological Chemistry·J J Smith, R A Rachubinski
Jan 9, 2001·Trends in Cell Biology·V I Titorenko, R A Rachubinski

❮ Previous
Next ❯

Citations

Dec 14, 2011·Journal of Industrial Microbiology & Biotechnology·Juan-Francisco MartínCarlos García-Estrada
Sep 3, 2002·FEMS Microbiology Letters·Sanda RocakIvana Weygand-Durasevic
Aug 2, 2003·Current Opinion in Cell Biology·Paul B Lazarow
Jul 3, 2013·Nature Structural & Molecular Biology·Dongqing PanHiroaki Kato
Jan 25, 2013·The Journal of Biological Chemistry·Xueqian Liu, Suresh Subramani
Feb 18, 2003·Molecular Biology of the Cell·Martin SichtingHanspeter Rottensteiner
May 31, 2012·Molekuliarnaia biologiia·A A Sibirnyĭ
Oct 7, 2003·Annual Review of Genomics and Human Genetics·Sabine WellerDavid Valle
Nov 5, 2005·FEMS Yeast Research·Katja GunkelIda J van der Klei
Aug 12, 2005·Molecular Membrane Biology·Paul A M MichelsVéronique Hannaert
Jul 25, 2008·Molecular Membrane Biology·Laura-Anne Brown, Alison Baker
Nov 17, 2004·The Journal of Cell Biology·Devi M NairPaul B Lazarow
Jan 5, 2006·The Journal of Cell Biology·Sébastien LéonSuresh Subramani
Feb 15, 2015·Journal of Molecular Biology·P K Kim, E H Hettema
Jun 12, 2012·Current Opinion in Cell Biology·Xueqian LiuSuresh Subramani
Jul 27, 2010·European Journal of Cell Biology·Markus DeckersRalf Erdmann
Sep 27, 2015·Biochimica Et Biophysica Acta·Laura L CrossAlison Baker
May 12, 2005·The FEBS Journal·Ines Heiland, Ralf Erdmann
May 21, 2009·IUBMB Life·Changle Ma, Suresh Subramani
Feb 3, 2004·Journal of Cellular and Molecular Medicine·Laura-Anne Brown, Alison Baker
Jul 16, 2010·The FEBS Journal·Janina WolfRalf Erdmann
Feb 12, 2010·Biology of the Cell·Thomas Lanyon-HoggAlison Baker
Oct 10, 2015·Biochimica Et Biophysica Acta·Leonidas EmmanouilidisMichael Sattler
Jan 13, 2006·Journal of Molecular Biology·Andreia F CarvalhoJorge E Azevedo
Nov 13, 2004·FEMS Microbiology Reviews·Juliette MoyersoenPaul A M Michels
Dec 5, 2006·Biochimica Et Biophysica Acta·Will A Stanley, Matthias Wilmanns
May 29, 2007·Biochimica Et Biophysica Acta·Andreia F CarvalhoJorge E Azevedo
Mar 7, 2009·Biochimica Et Biophysica Acta·Non MiyataYukio Fujiki
Sep 26, 2006·Biochimica Et Biophysica Acta·Paul B Lazarow
Oct 10, 2006·Biochimica Et Biophysica Acta·Naganand Rayapuram, Suresh Subramani
Oct 10, 2006·Biochimica Et Biophysica Acta·Sven Thoms, Ralf Erdmann
Oct 10, 2006·Biochimica Et Biophysica Acta·Wolfgang Schliebs, Wolf-H Kunau
Feb 18, 2017·Scientific Reports·Nadal A Al SaryiEwald H Hettema
Mar 29, 2002·Yeast
Aug 9, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Tânia FranciscoJorge E Azevedo
Sep 22, 2017·Cell Cycle·Wei Wang, Suresh Subramani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.