Abstract
The family of Nha antiporters mediating the efflux of alkali metal cations in exchange for protons across the plasma membrane is conserved in all yeast species. Yarrowia lipolytica is a dimorphic yeast, phylogenetically very distant from the model yeast Saccharomyces cerevisiae. A search in its sequenced genome revealed two genes (designated as YlNHA1 and YlNHA2) with homology to the S. cerevisiae NHA1 gene, which encodes a plasma membrane alkali metal cation/H+ antiporter. Upon heterologous expression of both YlNHA genes in S. cerevisiae, we showed that Y. lipolytica antiporters differ not only in length and sequence, but also in their affinity for individual substrates. While the YlNha1 protein mainly increased cell tolerance to potassium, YlNha2p displayed a remarkable transport capacity for sodium. Thus, Y. lipolytica is the first example of a yeast species with two plasma membrane alkali metal cation/H+ antiporters differing in their putative functions in cell physiology; cell detoxification vs. the maintenance of stable intracellular pH, potassium content and cell volume.
References
Jan 1, 1987·Gene·C S Hoffman, F Winston
Sep 1, 1986·Yeast·J E HillA Tzagoloff
May 27, 1996·FEBS Letters·C PriorH Sychrova
Apr 1, 1997·FEMS Microbiology Reviews·G Barth, C Gaillardin
Feb 14, 1998·Gene·C S ParkD D Ryu
Nov 5, 1998·Microbiology·Maria A BaAueIosSerge Potier
Feb 29, 2000·Biochimica Et Biophysica Acta·A Rodríguez-Navarro
Jan 12, 2001·FEBS Letters·S CasaregolaC Gaillardin
May 22, 2001·Molecular Microbiology·O KinclováH Sychrová
Aug 28, 2001·FEBS Letters·O KinclováH Sychrová
Apr 5, 2002·Microbiology·Olga KinclováHana Sychrová
Oct 29, 2002·Yeast·María A BañuelosSerge Potier
Aug 2, 2003·International Journal of Food Microbiology·R Vasdinyei, T Deák
Apr 6, 2004·Journal of Biotechnology·Catherine MadzakJean-Marie Beckerich
Jul 2, 2004·Nature·Bernard DujonJean-Luc Souciet
Jan 12, 2005·American Journal of Physiology. Cell Physiology·Christopher L BrettRajini Rao
Mar 15, 2005·Cell Biology International·Renata Zvyagilskaya, Bengt L Persson
Jun 14, 2005·Biochimica Et Biophysica Acta·Ryuichi OhgakiHiroshi Kanazawa
Jul 5, 2005·The Journal of Biological Chemistry·Olga Kinclova-ZimmermannovaHana Sychrova
Sep 20, 2005·Genome Biology·David J EideJeffrey F Harper
Nov 24, 2005·Gene·Klara Velkova, Hana Sychrova
Citations
May 3, 2008·Folia Microbiologica·K Papousková, H Sychrová
Mar 4, 2010·Microbiology and Molecular Biology Reviews : MMBR·Joaquín AriñoHana Sychrová
May 22, 2008·BMC Microbiology·Yannick Krauke, Hana Sychrova
Apr 9, 2008·Bioscience, Biotechnology, and Biochemistry·Yasuo WatanabeYouichi Tamai
Jul 24, 2010·Biochimica Et Biophysica Acta·Alonso Rodríguez-Navarro, Begoña Benito
Jul 2, 2015·FEMS Yeast Research·Dorota RadeckaJohan M Thevelein
Sep 2, 2008·Fungal Genetics and Biology : FG & B·Lenka PribylovaHana Sychrova
Feb 3, 2007·FEMS Yeast Research·Klara Papouskova, Hana Sychrova
Oct 15, 2010·FEMS Yeast Research·Yannick Krauke, Hana Sychrova
Jan 19, 2011·FEMS Microbiology Letters·José RamosHana Sychrová
May 18, 2016·FEMS Yeast Research·Hana ElicharováHana Sychrová
Sep 8, 2018·Yeast·Joaquín AriñoHana Sychrova
Mar 11, 2018·Applied Microbiology and Biotechnology·Asma TimoumiNathalie Gorret
Jul 31, 2007·Microbiology·Olga Kinclova-Zimmermannova, Hana Sychrová
Aug 31, 2020·Molecular Microbiology·Klara PapouskovaOlga Zimmermannova
Nov 26, 2020·Life·Maria Priscila LacerdaCarrie Eckert
Feb 18, 2021·FEMS Yeast Research·Dmitry Mamaev, Renata Zvyagilskaya
Jan 13, 2018·International Journal of Food Microbiology·Hana Dibalova-CulakovaHana Sychrova