YB-1 and MTA1 protein levels and not DNA or mRNA alterations predict for prostate cancer recurrence

Oncotarget
Christine Moore SheridanDavide Ruggero

Abstract

Attempts to identify biomarkers to detect prostate tumorigenesis, and thus minimize prostate cancer progression and inform treatment decisions have primarily focused on alterations at the DNA and mRNA levels, ignoring alterations at the level of protein synthesis control. We have previously shown that the PI3K-AKT-mTOR pathway, frequently deregulated in prostate cancer, specifically induces the synthesis of proteins that contribute to metastasis, most notably YB-1 and MTA1, without altering mRNA levels thereby demonstrating the importance of translation control in driving the expression of these genes in cancer.Here, we analyze genomic sequencing and mRNA expression databases, as well as protein expression employing an annotated tissue microarray generated from 332 prostate cancer patients with 15 years of clinical follow-up to determine the combined prognostic capability of YB-1 and MTA1 alterations in forecasting prostate cancer outcomes. Remarkably, protein abundance, but not genomic or transcriptional alterations of YB-1 and MTA1, is predictive of disease recurrence, exhibiting a dose-dependent effect on time to PSA recurrence, an indicator of tumor relapse. Moreover, high protein levels of YB-1 and MTA1 are associated with...Continue Reading

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Citations

Oct 5, 2017·International Journal of Molecular Sciences·U-Ging LoJer-Tsong Hsieh
Apr 27, 2016·Nature Reviews. Cancer·Morgan L Truitt, Davide Ruggero
Apr 27, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yimin LuXudong Lu
Oct 30, 2015·Oncotarget·Bàrbara CastellanaSantiago Ramón Y Cajal
May 19, 2017·Cancer Discovery·Franklin W HuangLevi A Garraway
Sep 17, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Vijaya Lakshmi MalisettyBramanandam Manavathi
Apr 10, 2019·Trends in Cancer·Samantha L Schuster, Andrew C Hsieh
Jul 6, 2021·Cellular Signalling·Akram AlkrekshiKhalid Sossey-Alaoui
Jun 25, 2021·International Journal of Radiation Oncology, Biology, Physics·Konstanze LettauMahmoud Toulany

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Software Mentioned

SAS
R
Keyence BZ Image Analysis
MATLAB Image Processing Toolbox
MATLAB
SPSS
CPE

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