YBX1 at the crossroads of non-coding transcriptome, exosomal, and cytoplasmic granular signaling

European Journal of Cell Biology
Padmanaban S SureshThejaswini Venkatesh

Abstract

YBX1 (Y box binding protein 1) is an RNA-/DNA-binding multifunctional protein harboring the classical cold shock protein (CSD) domain, an A/P domain, and a long C-terminal domain with alternating positively and negatively charged amino acids. It is a well-established oncogenic transcriptional factor, and regulates apoptosis, translation, cell proliferation, mRNA splicing, repair, differentiation, and stress response. The non-coding transcriptome has added yet another layer of complexity to the YBX1-mediated master regulation of cellular functions. Interestingly, YBX1 has been shown to localize to cytoplasmic granules such as P granules and stress granules. These granules regulate the non-coding transcriptome profile as well as mRNA translation and degradation. In this review, we discuss the recent findings on YBX1 signaling as mediated by various classes of non-coding RNAs, and on the functions of YBX1 at P granules, stress granules, exosomes, and mitochondria. YBX1 is a well-established target for cancer therapy and understanding its functions at organelles and ncRNA transcriptomes will shed new insights for devising organelle based anti-cancer therapies.

Citations

Jan 9, 2020·Scientific Reports·Dilara AyyildizSilvano Piazza
Feb 23, 2020·International Journal of Molecular Sciences·Stefan BauersachsCarmen Almiñana
Sep 5, 2019·Journal of Experimental & Clinical Cancer Research : CR·Yong WangDan Yue
Oct 22, 2019·Frontiers in Cell and Developmental Biology·Thomas G JohnsonGlen Reid
Sep 28, 2018·Cell Communication and Signaling : CCS·Jonathan A Lindquist, Peter R Mertens
Jul 8, 2020·Heart Failure Reviews·Toktam MoghimanAmir Abbas Momtazi-Borojeni
Jan 1, 2021·Progress in Retinal and Eye Research·Andrew P VoigtRobert F Mullins
Jan 14, 2021·Wiley Interdisciplinary Reviews. RNA·Yu-Sheng ChenYun-Gui Yang
Jan 5, 2021·Journal of Extracellular Vesicles·Fabrizio FabbianoVito G D'Agostino
Dec 6, 2020·FEBS Open Bio·Chen HuangXiaohua Douglas Zhang
Jun 8, 2021·Frontiers in Cell and Developmental Biology·Danai GeorgiadouMarie van Dijk

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