Yearly reduction of glucocorticoid dose by 50% as tapering schedule achieves complete remission for 124 pemphigus vulgaris patients

The Journal of Dermatology
Mingyue WangXuejun Zhu

Abstract

Glucocorticoids are the first-line treatment for pemphigus vulgaris. Among 140 patients receiving systemic glucocorticoids, 124 patients achieved complete remission off or on a prednisone dose of ≤10 mg/day or less for 6 months or more. The mean average steroid controlling doses were 0.65, 0.62, 0.80, 1.08 and 1.38 mg/kg per day for the mucosal-dominant patients and the mild, moderate, severe and extensive cutaneous-involved patients, respectively (P < 0.001). The mean durations of the initial tapering after controlling doses started were 77.98, 48.78, 31.74 and 28.83 days when the disease was controlled with doses of 40 mg/day or less, 45-60 mg/day, 65-80 mg/day and more than 80 mg/day for the cutaneous-involved types, respectively (P < 0.005). Of the patients, 79.51% achieved complete remission within 3 years, 98.36% within 5 years and all within 6 years, which corresponded to a 50% yearly reduction of glucocorticoid dose. These successfully treated patients indicate that a severity-tailored initial dose of glucocorticoids, an initial tapering duration based on the initial dose and a subsequent 50% yearly tapering regimen may cure pemphigus vulgaris within 3-6 years.

References

Feb 1, 1996·Archives of Dermatology·J C Bystryn, N M Steinman
Feb 25, 2000·Journal of the American Academy of Dermatology·A Herbst, J C Bystryn
Nov 25, 2003·The British Journal of Dermatology·K E HarmanUNKNOWN British Association of Dermatologists
Mar 15, 2008·Journal of the American Academy of Dermatology·Dedee F MurrellVictoria P Werth
Jun 4, 2008·Expert Opinion on Pharmacotherapy·Takashi Hashimoto
Apr 10, 2009·The Journal of Investigative Dermatology·Misha RosenbachVictoria P Werth
May 25, 2011·Dermatologic Clinics·Supriya S Venugopal, Dédée F Murrell
Sep 20, 2011·Dermatologic Clinics·John W FrewDédée F Murrell
Jun 29, 2013·Clinics in Dermatology·Eleonora RuoccoAda Lo Schiavo
Jun 10, 2014·The Journal of Dermatology·Masayuki AmagaiYasuo Kitajima
Feb 7, 2015·Drugs·Cathy Y Zhao, Dedee F Murrell

❮ Previous
Next ❯

Citations

Oct 13, 2017·Journal of Cutaneous Medicine and Surgery·Mathew N NicholasMarlene Dytoc
Sep 3, 2019·The Journal of Investigative Dermatology·Shengru ZhouMeng Pan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives of Dermatology and Syphilology
M J COSTELLO
Archives of Dermatology and Syphilology
T J RIORDAN
Archives of Dermatology and Syphilology
F C COMBES
© 2021 Meta ULC. All rights reserved