Yeast β-d-glucans induced antimicrobial peptide expressions against Salmonella infection in broiler chickens

International Journal of Biological Macromolecules
Yujing ShaoHaibo Zhang

Abstract

The present study was designed to investigate the effects of yeast β-d-glucans (YG) on gene expression of endogenous β-defensins (AvBDs), cathelicidins (Cath) and liver-expressed antimicrobial peptide-2 (LEAP-2) in broilers challenged with Salmonella enteritidis (SE). 240 day-old Cobb male broilers were randomly assigned to 2×2 factorial arrangements of treatments with two levels of dietary YG (0 or 200mg/kg in diet) and two levels of SE challenge (0 or 1×10(9) SE at 7-9 days of age). The results showed SE infection reduced growth performance,and increased salmonella cecal colonization and internal organs invasion, increased concentration of intestinal specific IgA and serum specific IgG antibody, as compared to uninfected birds. SE challenge differentially regulated AvBDs, Caths and LEAP-2 gene expression in the jejunum and spleen of broiler chickens during the infection period. However, YG supplementation inhibited the growth depression by SE challenge, and further increased level of serum specific IgG and intestinal specific IgA antibody. Higher level of salmonella colonization and internal organs invasion in the SE-infected birds were reduced by YG. SE-induced differentially expression patterns of AMPs genes was inhibited o...Continue Reading

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Sep 12, 2017·Critical Reviews in Microbiology·Gayatri SureshStephane Godbout
Aug 24, 2019·Journal of Animal Physiology and Animal Nutrition·Junqiu LuoDaiwen Chen
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Jul 29, 2021·Environmental Science and Pollution Research International·Amr El-SayedMohamed Kamel

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