Yeast β-glucan alleviates cognitive deficit by regulating gut microbiota and metabolites in Aβ1-42-induced AD-like mice.

International Journal of Biological Macromolecules
Mengdai XuLiegang Liu

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that remarkably imposes a huge global public health burden. Yeast β-glucans have been incorporated in functional foods and used in prophylactic applications owing to their biological effects. However, few studies had investigated the effects of yeast β-glucans on neurodegenerative diseases. Here, gut microbiota and metabolites SCFAs were analyzed through high-throughput 16S rRNA gene sequencing and GC-MS, respectively. Results indicated that yeast β-glucans could prominently shape the intestinal flora and produce SCFAs. Aβ1-42-induced AD mice treated with small-molecular yeast β-glucan (S-β-Glu) or macro-molecular yeast β-glucan (M-β-Glu) exhibited evident alterations of the composition of the gut microbiota, especially in some beneficial bacteria and inflammatory-related bacteria such as Lactobacillus, Bifidobacterium, Desulfovibrio, Oscillibacter, Mucispirillum, Alistipes, Anaerotruncus, and Rikenella. M-β-Glu regulated gut microbiota act as prebiotics better than S-β-Glu. Correlation analysis demonstrated the key microbiota closely associated with AD-related pathologies and cognition. Moreover, M-β-Glu and S-β-Glu ameliorated neuroinflammation and brain insulin resistan...Continue Reading

Citations

Dec 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lin-Xiu GuoTie-Jie Wang
Apr 27, 2021·Pharmacology & Therapeutics·Xiao-Yuan MaoWei-Lin Jin
Apr 18, 2021·International Journal of Biological Macromolecules·Pedro J Fernandez-JuliaDouwe van Sinderen
Jul 6, 2021·Frontiers in Cellular and Infection Microbiology·Qi LiliWang Jinbo
Aug 12, 2021·Comprehensive Reviews in Food Science and Food Safety·Patricia R PereiraVania M F Paschoalin
Aug 24, 2021·Frontiers in Psychiatry·Mariana RomanenkoAlexander Vaiserman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.