Yeast as a model host to explore plant virus-host interactions

Annual Review of Phytopathology
Peter D Nagy

Abstract

The yeast Saccharomyces cerevisiae is invaluable for understanding fundamental cellular processes and disease states of relevance to higher eukaryotes. Plant viruses are intracellular parasites that take advantage of resources of the host cell, and a simple eukaryotic cell, such as yeast, can provide all or most of the functions for successful plant virus replication. Thus, yeast has been used as a model to unravel the interactions of plant viruses with their hosts. Indeed, genome-wide and proteomics studies using yeast as a model host with bromoviruses and tombusviruses have facilitated the identification of replication-associated factors that affect host-virus interactions, virus pathology, virus evolution, and host range. Many of the host genes that affect the replication of the two viruses, which belong to two dissimilar virus families, are distinct, suggesting that plant viruses have developed different ways to utilize the resources of host cells. In addition, a surprisingly large number of yeast genes have been shown to affect RNA-RNA recombination in tombusviruses; this opens an opportunity to study the role of the host in virus evolution. The knowledge gained about host-virus interactions likely will lead to the develop...Continue Reading

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Citations

Dec 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Judit PoganyPeter D Nagy
Oct 21, 2011·Journal of Virology·Kunj B PathakPeter D Nagy
Oct 22, 2010·Journal of Virology·Hannah M JaagPeter D Nagy
Dec 18, 2009·Journal of Virology·Monika SharmaPeter D Nagy
Apr 30, 2009·Annual Review of Phytopathology·Said A Ghabrial, Nobuhiro Suzuki
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Nov 17, 2011·PloS One·Frederic AparicioJosé Ramón Murguía
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Feb 24, 2012·PLoS Pathogens·Nikolay KovalevPeter D Nagy
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Apr 15, 2011·Uirusu·Sotaro ChibaNobuhiro Suzuki
Mar 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tiziana MasciaDonato Gallitelli
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Oct 24, 2012·Current Opinion in Virology·Ying-Wen HuangYau-Heiu Hsu
Dec 4, 2012·Current Opinion in Virology·Peter D Nagy, Christopher D Richardson
Nov 6, 2012·Current Opinion in Virology·Peter D NagyJudit Pogany
Oct 23, 2012·Current Opinion in Virology·Akira Mine, Tetsuro Okuno
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Jan 10, 2012·Virus Research·Sandra Martínez-Turiño, Carmen Hernández
Mar 24, 2012·Current Opinion in Virology·Kunj B PathakPeter D Nagy
Jul 11, 2012·Journal of Biomedicine & Biotechnology·Marie-Line Andréola, Simon Litvak
Mar 13, 2014·Virology·Pui Kei K Lee, K Andrew White

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Methods Mentioned

BETA
chips
confocal microscopy
Two-Hybrid
Y2H
sumoylation
Three-Hybrid
Y3H
chip
affinity purification

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