Yeast mutants auxotrophic for choline or ethanolamine.

Journal of Bacteriology
K D AtkinsonS Fogel

Abstract

Three mutants of the yeast Saccharomyces cerevisiae which require exogenous ethanolamine or choline were isolated. The mutants map to a single locus (cho1) on chromosome V. The lipid composition suggests that cho1 mutants do not synthesize phosphatidylserine under any growth conditions. If phosphatidylethanolamine or phosphatidylcholine, which are usually derived from phosphatidylserine, were synthesized from exogenous ethanolamine or choline, the mutants grew and divided relatively normally. However, mitochondrial abnormalities were evident even when ethanolamine and choline were supplied. Diploids homozygous for the cho1 mutation were defective in sporulation. Growth on nonfermentable carbon sources was slow, and a high proportion of respiratory-deficient (petite) cells were generated in cho1 cultures.

References

Jan 1, 1978·Annals of the New York Academy of Sciences·D PapahadjopoulosW Pangborn
Jan 1, 1979·Cold Spring Harbor Symposia on Quantitative Biology·S FogelF Tavares
Apr 1, 1977·Journal of Bacteriology·S A HenryM R Culbertson
Jan 1, 1978·Annual Review of Biochemistry·J E Cronan
May 1, 1975·Genetics·M R Culbertson, S A Henry
Jan 1, 1975·Annual Review of Biochemistry·D F Silbert
Dec 1, 1971·Chemistry and Physics of Lipids·S A Henry, A D Keith
Jan 27, 1972·Biochimica Et Biophysica Acta·S Steiner, R L Lester
Oct 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·E Schweizer, H Bolling
Jan 1, 1971·Molecular & General Genetics : MGG·S A Henry, S Fogel
Mar 1, 1971·Journal of Bacteriology·C J Waechter, R L Lester
Sep 1, 1965·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·G LindegrenC C Lindegren
Sep 1, 1966·Journal of Bacteriology·M A Resnick, R K Mortimer
Dec 31, 1949·Nature·C S HANES, F A ISHERWOOD

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Citations

Jun 7, 1996·The Journal of Biological Chemistry·G M Carman, G M Zeimetz
Jul 21, 1998·The Journal of Biological Chemistry·D B OstranderG M Carman
Aug 2, 2003·The Journal of Biological Chemistry·Mary Elizabeth Gardocki, John M Lopes
Jul 27, 2004·Antimicrobial Agents and Chemotherapy·Rodolphe RoggeroChoukri Ben Mamoun
Aug 5, 2004·The Journal of Biological Chemistry·Vishal M GohilMiriam L Greenberg
Feb 10, 2006·The Journal of Biological Chemistry·Gil-Soo HanGeorge M Carman
May 20, 2009·The Journal of Membrane Biology·Nathan C RockwellJeremy Thorner
Jun 17, 2020·Journal of Lipid Research·Joanna M Kwiatek, George M Carman
Aug 11, 1995·The Journal of Biological Chemistry·V M McDonoughG M Carman
Oct 24, 2002·The Journal of Biological Chemistry·Marc M SchumacherDennis R Voelker
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·V Contamine, M Picard
Sep 6, 2005·The Journal of Biological Chemistry·Edward FisherJana Patton-Vogt
Mar 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·George M Carman, Michael C Kersting
Jun 12, 2003·The Journal of Biological Chemistry·June OshiroGeorge M Carman
Apr 25, 2008·The Journal of Biological Chemistry·Mária SimockováPeter Griac
Feb 1, 2011·Annual Review of Biochemistry·George M Carman, Gil-Soo Han
Sep 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yasunori UchidaHiroyuki Arai
Apr 2, 2015·The Journal of Biological Chemistry·Ouma OngukaSteven M Claypool
Nov 18, 2015·The Journal of Cell Biology·Alexandra GrippaPedro Carvalho
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·S M MandalaS Spiegel
Jun 2, 1995·The Journal of Biological Chemistry·W I WuG M Carman
Feb 6, 2020·Natural Product Reports·Shinichi Nishimura, Nobuaki Matsumori
Jan 1, 1984·Critical Reviews in Microbiology·A Chopra, G K Khuller
Mar 19, 2004·The Journal of Biological Chemistry·Wendy M IwanyshynGeorge M Carman

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