Yersinia enterocolitica serotype O:3 alters the expression of serologic HLA-B27 epitopes on human monocytes.

Infection and Immunity
M WuorelaKaisa Granfors

Abstract

The expression of serologic HLA-B27 epitopes on leukocytes of patients with reactive arthritis or ankylosing spondylitis has been shown to be modified in the course of the disease. The purpose of this work was to study whether phagocytosis of arthritis-triggering microbes in vitro alters the expression of HLA-B27 molecules on human antigen-presenting cells and to characterize the underlying mechanisms. Human monocytes and HLA-B27- or HLA-A2-transfected human U-937 cells were exposed to Yersinia enterocolitica serotype O:3. The expression of different epitopes of HLA-B27 was monitored by using immunofluorescence, and their synthesis was determined by quantitative immunoprecipitation. Our results show that phagocytosis of Y. enterocolitica serotype O:3 changed the expression of serological HLA-B27 epitopes. This was due to the reduced synthesis of HLA-B27 molecules. The expression of especially the epitopes which depend on the presence of peptides in the antigen-binding groove was changed. The expression of the ME1 epitope, which has been shown to be important for T-cell recognition in patients with reactive arthritis, was decreased. Down-regulation of epitopes important for the T-cell recognition may impair the elimination of ar...Continue Reading

References

Feb 4, 1978·Lancet·B AmorA E Georgiadis
May 15, 1976·International Journal of Cancer. Journal International Du Cancer·C Sundström, K Nilsson
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M A VegaJ A López de Castro
Jul 1, 1987·The Journal of Experimental Medicine·R D SalterP Parham
Apr 1, 1988·Arthritis and Rheumatism·M Leirisalo-Repo, H Suoranta
Sep 1, 1986·The Journal of Experimental Medicine·A F GeczyJ P Edmonds
Sep 1, 1974·Arthritis and Rheumatism·K AhoA Tiilikainen
Jan 1, 1982·Hybridoma·A E BergerP Cresswell
Aug 1, 1983·Human Immunology·J A TrapaniI F McKenzie
Aug 1, 1982·Human Immunology·S A EllisA McMichael
Aug 1, 1982·Human Immunology·F C GrumetE G Engleman
Apr 1, 1980·Journal of Clinical Microbiology·W J Laird, D C Cavanaugh
Dec 1, 1993·Infection and Immunity·M WuorelaK Granfors
Dec 1, 1994·The Journal of Experimental Medicine·M S VillanuevaE G Pamer
Dec 1, 1993·European Journal of Immunology·M A Whelan, J R Archer
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·H C GuoD C Wiley
Jul 1, 1996·European Journal of Immunology·X M GaoG Dougan

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Citations

Dec 21, 2000·Current Rheumatology Reports·M MartíJ A López de Castro
Jul 26, 2000·Current Opinion in Rheumatology·I Alvarez, J A López de Castro
May 22, 2013·Clinical & Developmental Immunology·Rosario PelusoRaffaele Scarpa
Jul 20, 1999·Current Opinion in Rheumatology·S GonzálezC López-Larrea
Apr 16, 2004·Clinical Microbiology Reviews·Inés ColmegnaLuis R Espinoza
Dec 22, 1999·Microbes and Infection·E J Bottone
May 25, 2002·Joint, Bone, Spine : Revue Du Rhumatisme·Jean-Marie BerthelotYves Maugars
Apr 1, 2000·Microbes and Infection·W P Maksymowych, K P Kane
Feb 3, 1999·Baillière's Clinical Rheumatology·L KoehlerA P Hudson

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