Yersinia pestis strains of ancient phylogenetic branch 0.ANT are widely spread in the high-mountain plague foci of Kyrgyzstan

PloS One
G A EroshenkoV V Kutyrev

Abstract

Fifty six Yersinia pestis strains, isolated over the period of more than 50 years in three high-mountain foci of Kyrgyzstan (Tien Shan, Alai, and Talas), have been characterized by means of PCR and single nucleotide polymorphism (SNP) typing methods. Seven of these strains were also characterized by means of whole genome sequencing and genome-wide SNP phylogenetic analysis. It was found that forty two strains belong to 0.ANT2, 0.ANT3 and 0.ANT5 phylogenetic branches. From these, strains of 0.ANT2 and 0.ANT3 branches were earlier detected in China only, whereas 0.ANT5 phylogenetic branch was identified for Y. pestis phylogeny for the first time. According to the results of genome-wide SNP analysis, 0.ANT5 strains are ones of the most closely related to Y. pestis strain responsible for the Justinianic Plague. We have also found out that four of the studied strains belong to the phylogenetic branch 2.MED1, and ten strains from Talas high-mountain focus belong to the phylogenetic branch 0.PE4 (sub-branch 0.PE4t). Established diversity of Y. pestis strains and extensive dissemination of the strains pertaining to the 0.ANT branch confirm the antiquity of the mentioned above plague foci and suggest that strains of the 0.ANT branch, wh...Continue Reading

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Citations

Mar 27, 2018·American Journal of Physical Anthropology·Anne L Grauer
May 8, 2020·Climacteric : the Journal of the International Menopause Society·Rod Baber
Apr 7, 2019·Nature Reviews. Genetics·Maria A SpyrouJohannes Krause
Jul 25, 2019·Frontiers in Veterinary Science·Gulmira SariyevaMichael Kosoy
Apr 12, 2020·Scientific Reports·Rémi BarbieriMichel Drancourt
Jun 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Marcel KellerJohannes Krause
Oct 6, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Irina MorozovaVerena J Schuenemann
Dec 11, 2020·Clinical Microbiology Reviews·R BarbieriM Drancourt
Oct 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·Meriam GuellilBarbara Bramanti
Jul 1, 2021·Cell Reports·Julian SusatBen Krause-Kyora

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Datasets Mentioned

BETA
JMUF00000000

Methods Mentioned

BETA
PCR

Software Mentioned

Wombac
PHYML
SPAdes GenomeAssembler
OpenStreetMap
Newbler gsAssembler
SeqMan DNASTAR Lasergene
Ion Torrent Suite

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