YH12852, a potent and highly selective 5-HT4 receptor agonist, significantly improves both upper and lower gastrointestinal motility in a guinea pig model of postoperative ileus

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Z HussainHyojin Park

Abstract

Postoperative ileus (POI) is a transient gastrointestinal (GI) dysmotility that commonly develops after abdominal surgery. YH12852, a novel, potent and highly selective 5-hydroxytryptamine 4 (5-HT4 ) receptor agonist, has been shown to improve both upper and lower GI motility in various animal studies and may have applications for the treatment of POI. Here, we investigated the effects and mechanism of action of YH12852 in a guinea pig model of POI to explore its therapeutic potential. The guinea pig model of POI was created by laparotomy, evisceration, and gentle manipulation of the cecum for 60 seconds, followed by closure with sutures under anesthesia. Group 1 received an oral administration of vehicle or YH12852 (1, 3, 10 or 30 mg/kg) only, while POI Group 2 was intraperitoneally pretreated with vehicle or 5-HT4 receptor antagonist GR113808 (10 mg/kg) prior to oral dosing of vehicle or YH12852 (3 or 10 mg/kg). Upper GI transit was evaluated by assessing the migration of a charcoal mixture in the small intestine, while lower GI transit was assessed via measurement of fecal pellet output (FPO). YH12852 significantly accelerated upper and lower GI transit at the doses of 3, 10, and 30 mg/kg and reached its maximal effect at 10...Continue Reading

References

Jul 5, 2001·European Journal of Pharmacology·M R BriejerJ A Schuurkes
Nov 7, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M R BriejerJ A Schuurkes
Sep 13, 2003·World Journal of Gastroenterology : WJG·Hui-Bin QiXin Liu
Sep 11, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A J Bauer, G E Boeckxstaens
Jan 27, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A N JamesH P Parkman
Feb 24, 2006·Archives of Surgery·Rob SchusterKenneth Waxman
May 9, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Eamonn M M QuigleyDavid Earnest
Aug 19, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Carlos M Villalón, David Centurión
Sep 4, 2007·Trends in Pharmacological Sciences·Roberto De GiorgioMarcello Tonini
Nov 6, 2007·Expert Opinion on Emerging Drugs·Beverley Greenwood-Van Meerveld
Jan 18, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J H De MaeyerJ A J Schuurkes
May 7, 2008·Drugs·Monique P Curran, Dean M Robinson
Aug 13, 2009·Gut·G E Boeckxstaens, W J de Jonge
Apr 23, 2010·Expert Opinion on Investigational Drugs·Noriaki ManabeMichael Camilleri
Jun 28, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nick J SpencerDamien J Keating
Nov 15, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P A BoakyeO B Balemba
Mar 9, 2012·Digestive Diseases and Sciences·Etsushi KawamuraNorifumi Kawada
May 28, 2013·Yonsei Medical Journal·Soo Jung ParkHyojin Park
Oct 24, 2013·World Journal of Gastroenterology : WJG·Hiroki MoritaHiroyuki Kuwano
Apr 1, 2014·World Journal of Surgery·Jeffrey F Barletta, Anthony J Senagore

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May 14, 2020·Expert Opinion on Therapeutic Patents·Caroline LanthierChristophe Rochais
Nov 14, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·John R KonenGary M Mawe

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