Yield of chest radiograph in tuberculosis screening for HIV-infected persons at a district-level HIV clinic

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
Duc T M NguyenEdward A Graviss

Abstract

An Hoa Clinic, a district-level human immunodeficiency virus (HIV) clinic in Ho Chi Minh City, Viet Nam. To assess the performance of chest radiograph (CXR) in screening for pulmonary tuberculosis (PTB) among HIV-infected individuals and identify misdiagnosed opportunities. This cross-sectional study was conducted in 397 HIV-infected patients consecutively enrolled at the An Hoa Clinic in Ho Chi Minh City, Viet Nam, from August 2009 to June 2010. The performance of CXR in TB screening was assessed based on its sensitivity, specificity, positive likelihood ratio and negative likelihood ratio. Symptom screening alone missed 50% of PTB cases. The combination of CXR and symptom screening yielded an additional 28.6% (8/28) in PTB screening as compared with symptom screening alone, and should be applied routinely, especially in high TB prevalent settings. CXR is a good predictor for PTB even in HIV-infected individuals. The combination of CXR and screening for common TB symptoms considerably improved the sensitivity of detecting active PTB in people living with HIV. If available, routine sputum culture and the World Health Organization-endorsed Xpert(®) MTB/RIF assay should be implemented to achieve a more accurate diagnosis.

Citations

Apr 14, 2017·Revista da Escola de Enfermagem da U S P·Fernando MitanoPedro Fredemir Palha
Jun 15, 2018·International Journal of Preventive Medicine·Masoud ShamaeiPayam Tabarsi
Mar 19, 2021·PloS One·Sally-Ann OheneMirjam Bakker
Apr 9, 2021·Tuberculosis Research and Treatment·Joanitah NalunjogiBruce Kirenga

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