Yield of clinical and radiographic surveillance in patients with resected pancreatic adenocarcinoma following multimodal therapy.

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Ching-Wei D TzengMatthew H G Katz

Abstract

Following potentially curative resection at this centre, patients with pancreatic adenocarcinoma (PAC) are routinely enrolled in a programme of clinical and radiographic surveillance. This study sought to evaluate its diagnostic yield. All patients who underwent pancreaticoduodenectomy for PAC at this institution during 1998-2008 were identified. Patients with asymptomatic recurrence were compared with those with symptomatic recurrence. Factors associated with survival following the detection of recurrence were compared. A total of 216 of 327 (66.1%) resected patients developed recurrence. Asymptomatic recurrence was detected in 118 (54.6%) patients. Symptomatic recurrence was associated with multifocal disease or carcinomatosis, poor performance status and less frequent subsequent therapy. Median time to recurrence did not differ between groups, but survival after detection was shorter in symptomatic patients (5.1 months vs. 13.0 months; P < 0.001). Treatment was administered more frequently to asymptomatic patients (91.2% vs. 61.4%; P < 0.001). At recurrence, a preserved performance status score of ≤ 1, further therapy, low CA 19-9, and an isolated site of recurrence were independently associated with longer post-recurrence s...Continue Reading

Associated Clinical Trials

Nov 10, 2020·Maria Chiara Bonini

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Citations

Oct 5, 2013·Annals of Surgical Oncology·Jason A Castellanos, Nipun B Merchant
Nov 19, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ching-Wei D TzengMatthew H G Katz
May 27, 2014·Journal of the American College of Surgeons·Amanda B CooperMatthew H G Katz
Mar 19, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T NordbyK J Labori
Mar 18, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Knut J LaboriIvar P Gladhaug
Sep 3, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ching-Wei D TzengMatthew H G Katz
Dec 30, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Raymond G DeobaldPaul J Karanicolas
Jul 10, 2016·Journal of Surgical Oncology·Anh-Thu Le, Ching-Wei D Tzeng
Oct 26, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jordan M CloydJeffrey E Lee
Jun 2, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alok A KhoranaMatthew H G Katz
Apr 27, 2016·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·E K AahlinK Lassen
Dec 16, 2016·Pancreas·Knut Jørgen Labori, Kristoffer Watten Brudvik
Dec 13, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jordan M CloydMatthew H G Katz
Nov 8, 2017·Abdominal Radiology·Eugene J KoayJoseph M Herman
Dec 10, 2015·Pancreas·Christine TjadenThilo Hackert
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Sep 28, 2017·Abdominal Radiology·Annabelle L Fonseca, Jason B Fleming
Mar 2, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Laura R PrakashMatthew H G Katz
Sep 22, 2019·International Journal of Molecular Sciences·Maximilian BrunnerGeorg F Weber
Jul 31, 2019·Journal of Clinical Medicine·Hsu WuSung-Hsin Kuo
Jan 16, 2015·Annals of Surgery·Yoshihiro MiseMatthew Harold G Katz
Dec 5, 2017·Abdominal Radiology·S JavadiE P Tamm
Aug 28, 2019·The British Journal of Surgery·M TanakaT Hackert
Apr 12, 2019·Journal of Gastrointestinal Cancer·David L ChanSimron Singh
Nov 6, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Yoshikuni KawaguchiJean-Nicolas Vauthey

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