Yield of emergent neuroimaging in children with new-onset seizure and status epilepticus

Seizure : the Journal of the British Epilepsy Association
Todd W LyonsA A Kimia

Abstract

To determine the yield of emergent neuroimaging among children with new-onset seizures presenting with status epilepticus. We performed a cross-sectional study of children seen at a single ED between 1995 and 2012 with new-onset seizure presenting with status epilepticus. We defined status epilepticus as a single seizure or multiple seizures without regaining consciousness lasting 30 min or longer. Our primary outcome was urgent or emergent intracranial pathology identified on neuroimaging. We categorized neuroimaging results as emergent if they would have changed acute management as assessed by a blinded neuroradiologist and neurologist. To ensure abnormalities were not missed, we review neuroimaging results for 30 days following the initial episode of SE. We included 177 children presenting with new-onset seizure with status epilepticus, of whom 170 (96%) had neuroimaging performed. Abnormal findings were identified on neuroimaging in 64/177 (36%, 95% confidence interval 29-43%) children with 15 (8.5%, 95% confidence interval 5.2-14%) children having urgent or emergent pathology. Four (27%) of the 15 children with urgent or emergent findings had a normal non-contrast computed tomography scan and a subsequently abnormal magnet...Continue Reading

References

Jul 1, 1988·Journal of Child Neurology·D W Dunn
Oct 15, 1994·BMJ : British Medical Journal·R A Schoenenberger, S M Heim
May 1, 1994·Epilepsia·S ShinnarS L Moshé
Apr 2, 1998·The New England Journal of Medicine·D H Lowenstein, B K Alldredge
Aug 8, 1998·The New England Journal of Medicine·R M Walls, M J Sagarin
Jan 30, 1999·Epilepsia·D H LowensteinR L Macdonald
May 13, 1999·Annals of Neurology·A T BergF M Testa
Mar 11, 2005·Indian Journal of Pediatrics·Sheffali GulatiM R Sridhar
Apr 20, 2007·Epilepsia·Itsuko NishiyamaKiyoshi Fujimoto
Jul 20, 2007·Epilepsia·Miquel Raspall-ChaureRod C Scott
Apr 25, 2009·Epilepsia·William D GaillardUNKNOWN ILAE, Committee for Neuroimaging, Subcommittee for Pediatric
Mar 29, 2012·Pediatric Emergency Care·Amir A KimiaMarvin Harper
Jul 22, 2015·Pediatrics·Peter S DayanNathan Kuppermann

❮ Previous
Next ❯

Citations

Apr 21, 2017·Journal of Child Neurology·Kara A BjurRandall P Flick
Apr 13, 2021·Seizure : the Journal of the British Epilepsy Association·María José Jiménez-VillegasJaime Carrizosa-Moog
May 1, 2021·Developmental Medicine and Child Neurology·Clodagh MitchellJay Shetty
May 8, 2021·Journal of the American College of Radiology : JACR·UNKNOWN Expert Panel on Pediatric ImagingBoaz Karmazyn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.