Yield of tuberculosis among household contacts of tuberculosis patients in Accra, Ghana

Infectious Diseases of Poverty
Sally-Ann OheneMirjam I Bakker

Abstract

The End TB Strategy calls for systematic screening of selected high-risk groups including contacts of tuberculosis (TB) cases to facilitate early TB case detection. Contact investigation is not usually routinely practiced in low TB burden countries, such as Ghana, with consequent paucity of data on the yield of TB case detection from such interventions. This study's objective was to document the outcomes and feasibility of implementing contact investigation activities under programmatic conditions in Ghana. Retrospective analyses were conducted of abstracted data from the National TB Program, following a contact investigation intervention for TB cases diagnosed in 10 facilities in Accra from June 2010 to December 2014. Various proportions and yield from number of contacts needed to screen (NNS) and number needed to test (NNT) to detect a TB case were assessed. Overall, out of the 8519 listed contacts of 3267 index cases, 8166 (96%) were screened and 614 (7.5%) were identified as presumptive TB. Out of these, 438 (71%) underwent sputum smear microscopy/evaluation and 53 TB cases were diagnosed. Of these, 56.6% were males, and 49% had sputum smear-positive TB, 38% had sputum smear-negative TB, and 7% had extra-pulmonary TB. The N...Continue Reading

References

Oct 31, 2003·American Journal of Epidemiology·D GuwatuddeC C Whalen
Dec 22, 2010·Paediatric Respiratory Reviews·Stephen M Graham
Mar 20, 2012·American Journal of Respiratory and Critical Care Medicine·Adrienne E ShapiroNeil A Martinson
Sep 1, 2012·The European Respiratory Journal·Gregory J FoxGuy B Marks
Jul 15, 2015·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·D JereneP G Suarez
May 18, 2016·Women's Health·Robyn Norton

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Citations

Sep 10, 2019·Frontiers in Cellular and Infection Microbiology·Michelle B Ryndak, Suman Laal
Aug 27, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·G QaderP G Suarez

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