Yin Yang 1 is a potent activator of human T lymphotropic virus type 1 LTR-driven gene expression via RNA binding.

Proceedings of the National Academy of Sciences of the United States of America
Gary Z Wang, Stephen P Goff

Abstract

Yin Yang 1 (YY1) is a DNA-binding transcription factor that either activates or represses gene expression. YY1 has previously been implicated in the transcriptional silencing of many retroviruses by binding to DNA sequences in the U3 region of the viral long terminal repeat (LTR). We here show that YY1 overexpression leads to profound activation, rather than repression, of human T lymphotropic virus type 1 (HTLV-1) expression, while YY1 down-regulation reduces HTLV-1 expression. The YY1 responsive element mapped not to YY1 DNA-binding sites in the HTLV-1 LTR but to the R region. The HTLV-1 R sequence alone is sufficient to provide YY1 responsiveness to a nonresponsive promoter, but only in the sense orientation and only when included as part of the mRNA. YY1 binds to the R region of HTLV-1 RNA in vitro and in vivo, leading to increased transcription initiation and elongation. The findings indicate that YY1 is a potent transactivator of HTLV-1 gene expression acting via binding viral RNA, rather than DNA.

References

Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N HariharanR P Perry
May 3, 1986·Lancet·M OsameM Tara
Sep 15, 1982·International Journal of Cancer. Journal International Du Cancer·W A BlattnerR C Gallo
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y HinumaI Miyoshi
Mar 25, 1995·Nucleic Acids Research·J S LeeY Shi
Dec 15, 1995·The Journal of Biological Chemistry·S BushmeyerM L Atchison
Apr 18, 1997·Biochimica Et Biophysica Acta·Y ShiK M Galvin
Jul 1, 1997·Molecular and Cellular Biology·K M Galvin, Y Shi
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 28, 2008·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Zachery R BelakNick Ovsenek
Sep 2, 2009·Genomics·Marcin Ratajewski, Lukasz Pulaski
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Matthew D DaughertyAlan D Frankel
Oct 19, 2010·Nature Structural & Molecular Biology·Matthew D DaughertyAlan D Frankel
Jul 7, 2011·Cell·Yesu Jeon, Jeannie T Lee
Jul 3, 2013·Cell Reports·Sharon SchlesingerStephen P Goff
Jul 6, 2014·The Journal of Biological Chemistry·Andrés López-PerroteOscar Llorca
Jul 23, 2015·The Journal of Biological Chemistry·Gary Z Wang, Stephen P Goff
Oct 31, 2015·Science·Alla A SigovaRichard A Young
Mar 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Yorifumi SatouCharles R M Bangham
Nov 2, 2016·Nucleic Acids Research·Dorothy C C WaiJoel P Mackay
Jan 13, 2018·International Journal of Cancer. Journal International Du Cancer·Levon M Khachigian
Jan 1, 2017·Critical Reviews in Oncogenesis·Fengyuan ChenHuating Wang

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Citations

May 21, 2021·Journal of Virology·Gary Z Wang, Stephen P Goff

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