Yin-Yang 1 regulates effector cytokine gene expression and T(H)2 immune responses.

The Journal of Allergy and Clinical Immunology
Jia GuoSteve N Georas

Abstract

The transcription factor Yin-Yang 1 (YY-1) binds to the promoter regions of several T-cell cytokine genes, but the expression and contribution of this factor to cytokine gene expression and T-cell activation in vivo is not clear. We sought to better define the role of YY-1 in T-cell gene regulation and allergic immune responses. We studied cytokine gene expression in T lymphocytes isolated from wild-type mice and heterozygous littermates bearing 1 targeted yy-1 allele (yy-1(+/-) mice). T cells were stimulated with anti-T-cell receptor (anti-TCR) plus CD28 antibodies or with peptide antigen plus antigen-presenting cells by using newly generated yy-1(+/-) TCR transgenic mice. We also studied ovalbumin-driven allergic immune responses in a mouse model of asthma and YY-1 expression in lung tissue from human asthmatic subjects. CD4(+) T cells from yy-1(+/-) mice secreted significantly less IL-4 and IFN-gamma compared with wild-type littermates after TCR-dependent activation, whereas IL-2 production was not significantly affected. Both airway inflammation and recall splenocyte IL-4 production were inhibited in yy-1(+/-) mice, as was antigen-driven T-cell proliferation. YY-1 expression was higher in airway biopsy specimens from asthma...Continue Reading

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Citations

Dec 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Soo Seok HwangGap Ryol Lee
Dec 21, 2010·American Journal of Respiratory and Critical Care Medicine·Xin LinJia Guo
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Dec 15, 2018·American Journal of Medical Genetics. Part a·Joel A Morales-RosadoRadhika Dhamija

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