YKL-40 A Sensitive Biomarker for Early Androgenetic Alopecia and Early Hidden Metabolic Syndrome

International Journal of Trichology
El-Habbak Doaa, Walid Abdel Abdel Halim

Abstract

Androgenetic alopecia (AGA) is a common dermatological problem, Does the onset of the AGA matters in the general health? YKL 40 may have role in the pathogenesis of early AGA and associated metabolic syndrome (MS). YKL 40, released by many inflammatory cells and its biological role is not well known. The estimation of serum level of YKL-40 in patients with AGA to detect its role in AGA and MS pathogenesis, onset and severity. This case-control study, 100 individuals were enrolled in our study; 70 AGA patients and 30 healthy controls. We obtained an informed written consent from each individual prior the participation. AGA was diagnosed clinically, and onset was evaluated as early onset alopecia (by the age of 30 years or earlier), YKL-40 level was measured by ELISA technique. Patients showed highly significant higher serum YKL-40 level more than that of the healthy subjects (P < 0.001). There was highly significant increase in YKL-40 level among early onset male and female cases compared to late onset cases (P < 0.001 each). There was significant increase in MS elements in AGA cases than controls (P < 0.05), and highly significant increase in MS associations and severity among early onset male and female cases compared to late ...Continue Reading

References

Jul 26, 1995·Biochemical and Biophysical Research Communications·S ItamiS Takayasu
Sep 6, 2000·International Journal of Dermatology·Y F MahéB A Bernard
Oct 13, 2000·Lancet·V MatilainenS Keinänen-Kiukaanniemi
Jul 18, 2001·Journal of Cardiovascular Risk·V A MatilainenS M Keinänen-Kiukaanniemi
Sep 6, 2002·Experimental Gerontology·Ralph M Trüeb
May 31, 2003·Journal of Cardiovascular Risk·Veikko MatilainenSirkka Keinänen-Kiukaanniemi
Apr 15, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Nanna JunkerPaul E G Kristjansen
Feb 24, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Julia S JohansenPaul A Price
Dec 25, 2007·Breast Cancer Research and Treatment·Anne RoslindEva Balslev
Mar 22, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·A Sadighha, G M Zahed
Dec 20, 2008·Clinical Endocrinology·José Gerardo González-GonzálezJesús Zacarías Villarreal-Pérez
Mar 3, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·A C DogramaciF Yalcin
May 15, 2009·The British Journal of Dermatology·L YipJ Ellis
Jul 28, 2009·Obesity Surgery·Moritz HempenGerit-Holger Schernthaner
Jan 5, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Mikkel AndreassenLars Ostergaard Kristensen
Apr 30, 2010·The British Journal of Dermatology·L-H Su, T H-H Chen
Jul 14, 2010·Journal of the American Academy of Dermatology·Salvador Arias-SantiagoRamón Naranjo-Sintes
Aug 28, 2010·The British Journal of Dermatology·U Blume-PeytaviUNKNOWN European Consensus Group
Dec 17, 2010·European Journal of Clinical Investigation·Johanna-M BrixGerit-H Schernthaner
Mar 30, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Zheng Jun LiYoung Lee
Sep 29, 2012·Experimental Dermatology·Shigeki Inui, Satoshi Itami
Mar 19, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·M T AgacS Celik
Aug 29, 2014·Indian Dermatology Online Journal·Ola Ahmed BakryAhmed Hassan
Sep 6, 2014·International Journal of Trichology·S ChakrabartyHemalini Suresh
Jan 28, 2015·Stroke; a Journal of Cerebral Circulation·Alisa D KjaergaardBørge G Nordestgaard
Dec 18, 2015·European Clinical Respiratory Journal·Jakob W HansenVibeke Backer
Dec 18, 2016·Journal of Cosmetic Dermatology·Hilal Kaya ErdoganOzkan Alatas
Apr 7, 2017·Folia medica·Maria H KazakovaVictoria S Sarafian
Aug 12, 2017·Scientific Reports·Rossella CannarellaAldo E Calogero
Jun 19, 2018·Indian Journal of Endocrinology and Metabolism·K C Dharam KumarVivekananda Neladimmanahally
Aug 2, 2018·Physiological Reviews·Max C Petersen, Gerald I Shulman

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS ( Statistical Package for Social Science )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.