Abstract
YKL-40 is secreted by macrophages in atherosclerotic lesions and involved in plaque rupture. YKL-40 is elevated in coronary artery disease, and predicts cardiovascular mortality. Experimental in vivo and in vitro data suggest a role of YKL-40 in tissue remodeling. A disease modulating potency of YKL-40 was not investigated in peripheral arterial disease (PAD). We measured YKL-40 in 460 subjects: 316 PAD: 71 normal glucose metabolism (PAD-NGM), 90 pre-diabetes (PAD-PREDM) and 155 diabetes (PAD-DM); 20 diabetes with atherosclerosis but without PAD (AS-DM); 85 diabetes without macro-vascular complications (DM) and 39 healthy controls (CO). YKL-40 is higher in PAD vs. CO (median [25-75 percentile]: 103 [69-159] vs. 43 [30-80]ng/ml; p<0.001). In addition, YKL-40 is elevated in DM (p<0.001), PAD-NGM (p=0.001), PAD-PREDM (p<0.001), PAD-DM (p<0.001) and AS-DM (p=0.002) compared to CO. Among PAD, YKL-40 is increased in PAD-PREDM (p=0.001) and PAD-DM (p=0.01) vs. PAD-NGM. By multivariate regression YKL-40 is significantly associated with age (beta=0.272), triglycerides (beta=0.216), aspartate-amino-transferase (beta=0.177) and c-reactive-protein (beta=0.178). Underpinning its role YKL-40 was found to be associated with micro-/macroalbumi...Continue Reading
References
Mar 25, 2000·The New England Journal of Medicine·P M RidkerN Rifai
Jun 30, 2000·Annals of the Rheumatic Diseases·K VosA M Boots
Jul 18, 2000·Journal of Hepatology·J S JohansenF Bendtsen
Jul 24, 2001·JAMA : the Journal of the American Medical Association·A D PradhanP M Ridker
Mar 29, 2003·Diabetes Care·Milla KallioMauri Lepäntalo
Jun 12, 2003·Experimental Cell Research·Kimi C Nishikawa, Albert J T Millis
Oct 22, 2004·Molecular & Cellular Proteomics : MCP·Estelle M FachGregory J Opiteck
Jan 16, 2007·Journal of Vascular Surgery·L NorgrenUNKNOWN TASC II Working Group
Jun 20, 2007·Circulation·Elizabeth L M BarrJonathan E Shaw
Jul 14, 2007·Coronary Artery Disease·Mine KucurSedat Tavsanoglu
Mar 11, 2008·Journal of Hypertension·Marc M H HermansCoen D A Stehouwer
May 16, 2008·Coronary Artery Disease·Camilla NøjgaardJulia S Johansen
Jun 4, 2008·Circulation·Linda L Demer, Yin Tintut
Jul 11, 2008·Scandinavian Cardiovascular Journal : SCJ·Yongzhong WangJens Kastrup
Jul 25, 2008·Diabetes·Anders R NielsenBente K Pedersen
Oct 30, 2008·Diabetes Care·Camilla Noelle RathckeHenrik Vestergaard
Mar 10, 2009·European Heart Journal·Jens KastrupUNKNOWN CLARICOR Trial Group
Jul 28, 2009·Obesity Surgery·Moritz HempenGerit-Holger Schernthaner
Jan 9, 2010·Atherosclerosis·Jian Lei ZhengWei Feng Shen
May 22, 2010·European Journal of Clinical Investigation·Georg SchallerGuntram Schernthaner
Oct 12, 2010·Diabetes Care·David Peter LorantGerit-Holger Schernthaner
Oct 26, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Naja Dam MygindUNKNOWN CLARICOR Trial Group
Oct 30, 2010·Annals of Neurology·Alisa D KjaergaardBørge G Nordestgaard
Dec 15, 2010·Cardiovascular Diabetology·Stine B ThomsenHenrik Vestergaard
Dec 17, 2010·European Journal of Clinical Investigation·Johanna-M BrixGerit-H Schernthaner
Aug 11, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Anders B MathiasenJens Kastrup
Citations
Jul 20, 2012·Cardiovascular Diabetology·Hyun Min KimHyun Chul Lee
Mar 26, 2013·Journal of Cancer Research and Clinical Oncology·Jing-Jing PanWen-Bin Liu
Dec 9, 2014·International Journal of Molecular Sciences·Semon WuYu-Lin Ko
May 21, 2015·International Journal of Molecular Sciences·Smriti Murali KrishnaJonathan Golledge
Apr 23, 2016·Diabetes Research and Clinical Practice·Louise KelstrupPeter Damm
Apr 3, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Guo ChenChang-Ming Xiong
Sep 19, 2015·Cardiovascular Diabetology·Eva AguileraManel Puig-Domingo
Nov 30, 2012·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Hector OrtegaWayne H Anderson
Aug 21, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·João RufoOlga Lourenço
Dec 17, 2014·Cytokine·Guillaume F BouvetYves Berthiaume
Apr 15, 2014·Mediators of Inflammation·Zushun GongQichong Xing
Jul 28, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Dorte Gybel-BraskEstrid V S Høgdall
Aug 25, 2016·Journal of Diabetes·Shao-Ling YangJing-Tao Dou
Jan 18, 2017·Biomarkers in Medicine·Yan JinCheng-Jian Yang
Oct 18, 2018·Acta Psychiatrica Scandinavica·I DiesetO A Andreassen
Aug 27, 2017·BMC Endocrine Disorders·Driton VelaRamadan B Sopi
Jul 21, 2017·Cardiovascular Diabetology·Alexander Tenenbaum, Enrique Z Fisman
Jul 10, 2017·Journal of Biomedical Science·Peggy Sfyri, Antonios Matsakas
Sep 16, 2020·Signal Transduction and Targeted Therapy·Ting ZhaoQiang You
Nov 27, 2019·European Journal of Preventive Cardiology·Giacomo BusoLucia Mazzolai
May 27, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Bernhard ZierfussGerit-Holger Schernthaner