YKL-40 is elevated in patients with peripheral arterial disease and diabetes or pre-diabetes

Atherosclerosis
Klaudija BatinicGerit-Holger Schernthaner

Abstract

YKL-40 is secreted by macrophages in atherosclerotic lesions and involved in plaque rupture. YKL-40 is elevated in coronary artery disease, and predicts cardiovascular mortality. Experimental in vivo and in vitro data suggest a role of YKL-40 in tissue remodeling. A disease modulating potency of YKL-40 was not investigated in peripheral arterial disease (PAD). We measured YKL-40 in 460 subjects: 316 PAD: 71 normal glucose metabolism (PAD-NGM), 90 pre-diabetes (PAD-PREDM) and 155 diabetes (PAD-DM); 20 diabetes with atherosclerosis but without PAD (AS-DM); 85 diabetes without macro-vascular complications (DM) and 39 healthy controls (CO). YKL-40 is higher in PAD vs. CO (median [25-75 percentile]: 103 [69-159] vs. 43 [30-80]ng/ml; p<0.001). In addition, YKL-40 is elevated in DM (p<0.001), PAD-NGM (p=0.001), PAD-PREDM (p<0.001), PAD-DM (p<0.001) and AS-DM (p=0.002) compared to CO. Among PAD, YKL-40 is increased in PAD-PREDM (p=0.001) and PAD-DM (p=0.01) vs. PAD-NGM. By multivariate regression YKL-40 is significantly associated with age (beta=0.272), triglycerides (beta=0.216), aspartate-amino-transferase (beta=0.177) and c-reactive-protein (beta=0.178). Underpinning its role YKL-40 was found to be associated with micro-/macroalbumi...Continue Reading

References

Jul 18, 2000·Journal of Hepatology·J S JohansenF Bendtsen
Jul 24, 2001·JAMA : the Journal of the American Medical Association·A D PradhanP M Ridker
Jun 12, 2003·Experimental Cell Research·Kimi C Nishikawa, Albert J T Millis
Oct 22, 2004·Molecular & Cellular Proteomics : MCP·Estelle M FachGregory J Opiteck
Jan 16, 2007·Journal of Vascular Surgery·L NorgrenUNKNOWN TASC II Working Group
Jul 14, 2007·Coronary Artery Disease·Mine KucurSedat Tavsanoglu
May 16, 2008·Coronary Artery Disease·Camilla NøjgaardJulia S Johansen
Jun 4, 2008·Circulation·Linda L Demer, Yin Tintut
Jul 11, 2008·Scandinavian Cardiovascular Journal : SCJ·Yongzhong WangJens Kastrup
Jul 25, 2008·Diabetes·Anders R NielsenBente K Pedersen
Jul 28, 2009·Obesity Surgery·Moritz HempenGerit-Holger Schernthaner
May 22, 2010·European Journal of Clinical Investigation·Georg SchallerGuntram Schernthaner
Oct 12, 2010·Diabetes Care·David Peter LorantGerit-Holger Schernthaner
Oct 26, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Naja Dam MygindUNKNOWN CLARICOR Trial Group
Oct 30, 2010·Annals of Neurology·Alisa D KjaergaardBørge G Nordestgaard
Dec 17, 2010·European Journal of Clinical Investigation·Johanna-M BrixGerit-H Schernthaner
Aug 11, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Anders B MathiasenJens Kastrup

❮ Previous
Next ❯

Citations

Mar 26, 2013·Journal of Cancer Research and Clinical Oncology·Jing-Jing PanWen-Bin Liu
May 21, 2015·International Journal of Molecular Sciences·Smriti Murali KrishnaJonathan Golledge
Apr 23, 2016·Diabetes Research and Clinical Practice·Louise KelstrupPeter Damm
Apr 3, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Guo ChenChang-Ming Xiong
Nov 30, 2012·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Hector OrtegaWayne H Anderson
Aug 21, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·João RufoOlga Lourenço
Dec 17, 2014·Cytokine·Guillaume F BouvetYves Berthiaume
Jul 28, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Dorte Gybel-BraskEstrid V S Høgdall
Aug 25, 2016·Journal of Diabetes·Shao-Ling YangJing-Tao Dou
Jan 18, 2017·Biomarkers in Medicine·Yan JinCheng-Jian Yang
Oct 18, 2018·Acta Psychiatrica Scandinavica·I DiesetO A Andreassen
Jul 21, 2017·Cardiovascular Diabetology·Alexander Tenenbaum, Enrique Z Fisman
Sep 16, 2020·Signal Transduction and Targeted Therapy·Ting ZhaoQiang You
Nov 27, 2019·European Journal of Preventive Cardiology·Giacomo BusoLucia Mazzolai
May 27, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Bernhard ZierfussGerit-Holger Schernthaner

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.