YKL-40 level in gingival crevicular fluid from patients with periodontitis and type 2 diabetes

Oral Diseases
Jun-Ichi KidoToshihiko Nagata

Abstract

YKL-40 is a chitin-binding glycoprotein, the level of which increases in inflammatory diseases, diabetes mellitus (DM), cardiovascular diseases, and tumors. Gingival crevicular fluid (GCF) contains many proteins and markers of periodontitis. The purpose of this study was to investigate YKL-40 level in GCF from patients with periodontitis and DM and the association between YKL-40 level and chronic periodontitis (CP) or DM. The subjects were 121 patients with DM, CP, DM and periodontitis (DM-P), and healthy subjects (H). GCF was collected using paper strips after the sites for GCF collection were clinically evaluated for probing depth (PD), gingival index (GI), and bleeding on probing (BOP). YKL-40 in GCF was identified by Western blotting, and its level was determined by ELISA. YKL-40 was contained in GCF samples from H, DM, CP, and DM-P sites, and its levels (amount and concentration) in CP and DM-P were significantly higher than those in H and DM. GCF YKL-40 level significantly correlated with PD and GI, and its level in BOP-positive sites was significantly higher than that in BOP-negative ones. GCF YKL-40 level was elevated in periodontitis, but not DM. YKL-40 in GCF may be an inflammatory marker for periodontitis.

References

Dec 8, 1998·Journal of Periodontal Research·J KidoT Nagata
Feb 24, 2001·Nature·C M SteppanM A Lazar
May 3, 2002·Clinical and Diagnostic Laboratory Immunology·Christian ØstergaardJens D Lundgren
Apr 4, 2003·International Journal of Colorectal Disease·Ioannis E KoutroubakisElias A Kouroumalis
Jun 12, 2003·Experimental Cell Research·Kimi C Nishikawa, Albert J T Millis
Dec 1, 1963·Acta Odontologica Scandinavica·H LOE, J SILNESS
Apr 30, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Nurdan Ozmeric
Apr 15, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Nanna JunkerPaul E G Kristjansen
Feb 24, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Julia S JohansenPaul A Price
Apr 14, 2006·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·C N RathckeH Vestergaard
Sep 7, 2006·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·C N Rathcke, H Vestergaard
Jul 14, 2007·Coronary Artery Disease·Mine KucurSedat Tavsanoglu
Jul 25, 2008·Diabetes·Anders R NielsenBente K Pedersen
Nov 26, 2009·Cardiovascular Diabetology·Camilla N Rathcke, Henrik Vestergaard
May 22, 2010·European Journal of Clinical Investigation·Georg SchallerGuntram Schernthaner
Aug 21, 2010·Endocrine Journal·Masafumi Koga, Soji Kasayama
Feb 15, 2011·Archives of Oral Biology·Yuka HiroshimaJun-Ichi Kido
Jun 24, 2011·Cardiovascular Diabetology·Anne K RøndbjergHenrik Vestergaard
Jan 3, 2012·Diabetes Research and Clinical Practice·Frederik PerssonPeter Rossing
Jan 10, 2012·Journal of Periodontal Research·J KidoT Nagata
Feb 13, 2013·The Journal of Dermatology·Yasutomo ImaiKiyofumi Yamanishi
May 1, 2013·The Journal of Allergy and Clinical Immunology·Jon R KonradsenGunilla Hedlin
Jun 12, 2013·Frontiers in Physiology·Rong Shao
Nov 28, 2013·International Journal of Endocrinology·Sharifah Intan Qhadijah Syed IkmalWan Azman Wan Ahmad
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Jan 21, 2014·Bone·Michelino Di RosaLucia Malaguarnera
Mar 19, 2014·Journal of Periodontology·Zeynep Pinar KelesGulnur Emingil
Nov 26, 2014·Molecular and Cellular Biochemistry·Gamze ErfanMustafa Kulac

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.