YKL-40, Soluble IL-2 Receptor, Angiotensin Converting Enzyme and C-Reactive Protein: Comparison of Markers of Sarcoidosis Activity

Biomolecules
Pelin UysalHafize Uzun

Abstract

The aims of this study were to describe the clinical, radiological and immunological features of a population of sarcoidosis patients and to analyse chitinase-3-like protein 1 (YKL-40), soluble interleukin-2 receptor (sIL-2R), neopterin concentrations and adenosine deaminase (ADA) activity in serum of these patients in order to understand their potential as disease markers. Fifty-nine patients affected by chronic sarcoidosis, in active (20 patients) and inactive (39 patients) phase according to the clinical, radiological and laboratory criteria were studied. Serum YKL-40, sIL-2R, high-sensitive C-reactive protein (hs-CRP), neopterin levels and ADA activities were evaluated and compared with those of 25 healthy controls. Individuals with chronic sarcoidosis were significantly higher serum YKL-40, sIL-2R, neopterin, hs-CRP concentrations, angiotensin converting enzyme (ACE) and ADA activity than those of control subjects. Sarcoidosis patients in the active phase of the disease were significantly higher YKL-40, sIL-2R, hs-CRP levels and ACE activity than those in the inactive phase, while ADA activities and neopterin levels did not display any significant difference between the active and inactive disease groups. In comparison to ...Continue Reading

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Citations

May 30, 2019·International Journal of Molecular Sciences·Marcin WłodarczykMarek Fol
Dec 24, 2019·Expert Review of Respiratory Medicine·Aman Pande, Daniel A Culver
Apr 7, 2020·Expert Review of Respiratory Medicine·M C SchimmelpenninkJ C Grutters
Aug 8, 2020·Frontiers in Immunology·Raisa KraaijvangerMarcel Veltkamp
Aug 25, 2020·Respiratory Medicine·Ying ZhouHuiping Li

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Methods Mentioned

BETA
bronchoalveolar lavage
biopsy
X-ray
enzyme-linked immunosorbent assay
sandwich immunoassay

Software Mentioned

statistical package for the social sciences ( SPSS )
SPSS

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