Yohimbine stress potentiates conditioned cue-induced reinstatement of heroin-seeking in rats.

Behavioural Brain Research
Kelly M BannaRonald E See

Abstract

Stress and drug-associated cues can trigger craving and relapse in abstinent drug-dependent individuals. Although the role of these two critical factors in relapse has been extensively studied, the interaction between stress and drug-associated cues in relapse has been less well characterized. Using an animal model of relapse, we assessed the effects of the pharmacological stressor, yohimbine (1.25 or 2.5mg/kg), on reinstatement of extinguished heroin-seeking in rats either in the presence or absence of heroin-associated cues. Yohimbine, in the absence of heroin-associated cues, and cues by themselves reliably reinstated heroin-seeking over extinction levels. Notably, animals showed significantly potentiated responding when yohimbine preceded cue-induced reinstatement (3-4x higher over cues or yohimbine alone). These results demonstrate that exposure to heroin-paired cues during yohimbine-induced stress greatly potentiates heroin-seeking, and support the simultaneous targeting of both stress and cue activation during relapse intervention.

References

Jun 1, 1990·British Journal of Addiction·D C DrummondS P Glautier
Jan 1, 1997·Archives of General Psychiatry·R K BroonerG E Bigelow
May 19, 1998·Journal of Psychopharmacology·C P O'BrienS J Robbins
Sep 1, 2000·Brain Research. Brain Research Reviews·Y ShahamJ Stewart
Jan 18, 2002·Psychopharmacology·R Sinha
Mar 26, 2003·Psychopharmacology·Peter W Kalivas, Krista McFarland
Apr 23, 2003·European Journal of Pharmacology·Herbert E Covington, Klaus A Miczek
Feb 12, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Buyean LeeRoger D Spealman
Jul 9, 2004·Annals of the New York Academy of Sciences·James P HermanHelmer Figueiredo
Nov 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer M BossertYavin Shaham
Jun 3, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bin WangZhi-Bing You
Jul 19, 2005·Drug and Alcohol Dependence·Wilson M Compton, Nora D Volkow
Oct 29, 2005·European Journal of Pharmacology·Ronald E See
Aug 22, 2006·Behavioural Brain Research·Matthew W Feltenstein, Ronald E See
Dec 16, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Michel Le Moal, George F Koob
Jul 7, 2007·The American Journal on Addictions·Erica DuncanClint Kilts
Aug 3, 2007·The American Journal of Psychiatry·George Koob, Mary Jeanne Kreek
Oct 6, 2009·Physiology & Behavior·Deanne M Buffalari, Ronald E See

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Citations

Jan 18, 2012·Psychopharmacology·Amanda T CampbellFrancesco Leri
Nov 20, 2012·Psychopharmacology·Mark K GreenwaldCaren L Steinmiller
Nov 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jeffrey A SimmsSelena E Bartlett
May 6, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James M Otis, Devin Mueller
May 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Joel E SchlosburgGeorge F Koob
Apr 9, 2014·Psychopharmacology·Megan M Moran-Santa MariaKathleen T Brady
Oct 9, 2012·Peptides·Richard J Bodnar
May 29, 2014·British Journal of Pharmacology·B Jupp, J W Dalley
May 9, 2015·Neurobiology of Stress·Michael V BarattaDonald C Cooper
Sep 29, 2011·Drug and Alcohol Dependence·Matthew W FeltensteinRonald E See
Mar 22, 2012·Journal of Dietary Supplements·Nevio Cimolai, Tomas Cimolai
Jan 15, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Serena StopponiRoberto Ciccocioppo
Nov 7, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kenzie L PrestonDavid H Epstein
Jul 12, 2019·Frontiers in Behavioral Neuroscience·Nathaniel P StaffordSergios Charntikov
Nov 5, 2019·Frontiers in Behavioral Neuroscience·Marc T J Exton-McGuinnessJonathan L C Lee
May 1, 2021·Journal of Personalized Medicine·Lynn M OswaldCarla L Storr

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