Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice

Journal of Ethnopharmacology
Toshiyuki UekiYoshio Kase

Abstract

Yokukansan, a traditional Japanese (Kampo) medicine, has recently been used to treat the behavioral and psychological symptoms of dementia (BPSD), including aggressiveness, excitability, and hallucination. The present study was designed to investigate the mechanisms underlying the ameliorative effects of yokukansan on BPSD using animals exhibiting hallucination-like behaviors. For this purpose, we initially examined whether chronic isolation stress increases the frequency of hallucination in response to a psychedelic drug. Using this animal model, we next examined the effects of yokukansan on drug-induced hallucination-like behaviors. Finally, we examined the density and mRNA levels of serotonin 2A (5-HT2A) receptors. Male mice were subjected to isolation stress for six weeks. Yokukansan was incorporated into food pellets, and administered to the mice for six weeks. In some experiments, yokukansan and each of seven constituent herbs were administered orally to the mice for the last two weeks during the six-week period of isolation stress. A 5-HT2A receptor agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI, 2.5mg/kg), was injected into the mice, and head-twitch behaviors were quantified. The binding sites of 5-HT2A receptors on the ...Continue Reading

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Citations

Jul 5, 2016·Pharmacology & Therapeutics·Yasushi Ikarashi, Kazushige Mizoguchi
Jun 2, 2020·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Motohiro OzoneMasahiro Shigeta
Jan 24, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jung-Hee JangChangjong Moon
Jun 4, 2020·Journal of General and Family Medicine·Shin TakayamaTadashi Ishii

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