Yorkie regulates epidermal wound healing in Drosophila larvae independently of cell proliferation and apoptosis

Developmental Biology
Chang-Ru TsaiMichael J Galko

Abstract

Yorkie (Yki), the transcriptional co-activator of the Hippo signaling pathway, has well-characterized roles in balancing apoptosis and cell division during organ growth control. Yki is also required in diverse tissue regenerative contexts. In most cases this requirement reflects its well-characterized roles in balancing apoptosis and cell division. Whether Yki has repair functions outside of the control of cell proliferation, death, and growth is not clear. Here we show that Yki and Scalloped (Sd) are required for epidermal wound closure in the Drosophila larval epidermis. Using a GFP-tagged Yki transgene we show that Yki transiently translocates to some epidermal nuclei upon wounding. Genetic analysis strongly suggests that Yki interacts with the known wound healing pathway, Jun N-terminal kinase (JNK), but not with Platelet Derived Growth Factor/Vascular-Endothelial Growth Factor receptor (Pvr). Yki likely acts downstream of or parallel to JNK signaling and does not appear to regulate either proliferation or apoptosis in the larval epidermis during wound repair. Analysis of actin structures after wounding suggests that Yki and Sd promote wound closure through actin regulation. In sum, we found that Yki regulates an epithelial...Continue Reading

References

Jan 21, 2012·Molecular Biology of the Cell·Laura J Stevens, Andrea Page-McCaw

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Citations

Feb 9, 2020·International Journal of Molecular Sciences·Georgia NikoloudakiDouglas W Hamilton
Mar 3, 2020·Frontiers in Cell and Developmental Biology·John E La Marca, Helena E Richardson
Jul 20, 2018·Development·Jan Inge Øvrebø, Bruce A Edgar
Aug 21, 2020·Cancer Research·Michal Shreberk-ShakedMoshe Oren
May 14, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Tuba TarhanMustafa Çulha

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