You Are What You (First) Eat

Frontiers in Human Neuroscience
Kelly L Buchanan, Diego V Bohórquez

Abstract

As far back as we can remember, we eat. In fact, we eat before we can remember. Our first meal is amniotic fluid. We swallow it during the first trimester of gestation, and with that, we expose our gut to a universe of molecules. These early molecules have a profound influence on gut and brain function. For example, the taste of the amniotic fluid changes based on the mother's diet. Indeed, recent findings suggest that food preferences begin in utero. Likewise, a baby's first exposure to bacteria, previously thought to be during birth, appears to be in utero as well. And just as postnatal food and microbiota are implicated in brain function and dysfunction, prenatal nutrients and microbes may have a long-lasting impact on the development of the gut-brain neural circuits processing food, especially considering their plasticity during this vulnerable period. Here, we use current literature to put forward concepts needed to understand how the gut first meets the brain, and how this encounter may help us remember food.

References

Nov 1, 1985·Early Human Development·J I de VriesH F Prechtl
Dec 1, 1985·Journal of Pediatric Surgery·S J MulvihillE W Fonkalsrud
Jan 30, 1999·The Journal of Pathology·A AndrewB B Rawdon
Jul 30, 1999·Histology and Histopathology·B F QianH Axelsson
Apr 13, 2000·Cell·E AdlerC S Zuker
Jun 5, 2001·Pediatrics·J A MennellaG K Beauchamp
Feb 21, 2002·The Journal of Veterinary Medical Science·Raden Harry SoehartonoHaruo Yamada
May 22, 2002·Anatomy and Embryology·C LuciniL Castaldo
Oct 22, 2002·American Journal of Obstetrics and Gynecology·Mostafa A El-HaddadMichael G Ross
Nov 15, 2003·Autonomic Neuroscience : Basic & Clinical·Marion RaabWinfried L Neuhuber
Sep 28, 2005·Current Microbiology·Esther JiménezJuan M Rodríguez
Dec 13, 2005·Nature·Craig A Micchelli, Norbert Perrimon
Jun 20, 2006·Developmental Biology·Jennifer M BatesKaren Guillemin
Aug 19, 2006·The Journal of Comparative Neurology·Elyanne M RatcliffeMichael D Gershon
Aug 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hyeung-Jin JangJosephine M Egan
Nov 21, 2007·Current Opinion in Pharmacology·Enrique Rozengurt, Catia Sternini
Feb 15, 2008·The ISME Journal·Seana K Davidson, David A Stahl
Feb 19, 2008·Research in Microbiology·Esther JiménezJuan M Rodríguez
Mar 28, 2008·Neuron·Ivan E de AraujoSidney A Simon
Apr 18, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H-R Berthoud
Jul 17, 2008·Genes & Development·Nick BarkerHans Clevers
Feb 12, 2010·Development·Allison J BardinFrançois Schweisguth
Jun 10, 2010·The Journal of Comparative Neurology·Michelle C Murphy, Edward A Fox
Feb 12, 2011·The American Journal of Clinical Nutrition·Julie A MennellaGary K Beauchamp
Aug 20, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E M RatcliffeE A Fox
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Javier A BravoJohn F Cryan
Mar 24, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anthony Sclafani, Karen Ackroff
Nov 8, 2012·Development·Catarina C F Homem, Juergen A Knoblich
Nov 20, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David GoldbergElyanne M Ratcliffe
Mar 13, 2014·PloS One·Alexandria N ArdissoneJosef Neu
Mar 29, 2014·Handbook of Experimental Pharmacology·B LuY Lu
May 23, 2014·Science Translational Medicine·Kjersti AagaardJames Versalovic

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Citations

Jun 26, 2021·Frontiers in Cellular Neuroscience·Aviva GarsNancy G Forger

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Methods Mentioned

BETA
PCR
cesarean section

Software Mentioned

Prospero

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