You Can't Always Get What You Want: The Influence of Choice on Nocebo and Placebo Responding

Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine
Hannah BartleyKeith J Petrie

Abstract

Choice may be an important influence on the effectiveness and side effects of medical treatments. We investigated the impact of having a choice of medication compared to no choice on both nocebo and placebo responding. Sixty-one participants were randomly assigned to either choose between or be assigned to one of the two equivalent beta-blocker medications (actually placebos) for pre-examination anxiety. There was a greater nocebo response in the no choice group and an increased placebo response in the choice group. Participants in the no choice group attributed significantly more side effects to the tablet than the choice group (p = 0.045), particularly at the 24-h follow-up (p = 0.002). The choice group showed a stronger placebo response in heart rate than the non-choice group. Not being given a choice of medication increased the nocebo effect and reduced the placebo response to the treatment.

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Citations

May 22, 2019·Psychology & Health·Kate MacKrillKeith J Petrie
Sep 11, 2019·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Valerie YeungBen Colagiuri
Dec 6, 2019·Zeitschrift für Rheumatologie·J BraunU Kiltz
Dec 17, 2016·Scandinavian Journal of Primary Health Care·P Lucassen, F Olesen
Jun 21, 2017·Current Opinion in Psychiatry·Antje D ArltWinfried Rief
Oct 4, 2017·Pain Reports·Maxie BlasiniLuana Colloca
Mar 17, 2018·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Jason El BrihiKate Faasse
Dec 19, 2019·Frontiers in Pharmacology·Luana CollocaT Kevin Murphy
Oct 26, 2016·Current Medical Research and Opinion·Andrei C SpositoUNKNOWN ; on behalf of the Luso-Latin American Consortium on Statin-Associated Muscle Symptoms
Sep 12, 2018·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Kate FaasseBen Colagiuri
May 24, 2021·Cognition·Kirsten BarnesBen Colagiuri

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