PMID: 3749009May 1, 1986Paper

Young adult cholesterol as a predictor of familial ischemic heart disease

Preventive Medicine
T ReedL H Kuller

Abstract

Family history for ischemic heart disease (IHD) was quantified from 229 questionnaires returned by the parents of young adults who had their total serum cholesterol levels determined as seventh graders in 1972-1973 and again 9 years later. The participants were divided into low- or high-cholesterol groups using quintiles. There were nonsignificant trends for higher prevalence of IHD in the families of individuals, principally the male participants, with persistently high total serum cholesterol levels; an excess of IHD in families of young adults with reduced high-density lipoprotein cholesterol (HDL); and a deficit of IHD in families of high-HDL participants. There was a significant interaction in family history scores between HDL and total cholesterol, such that there was an excess of IHD prevalence in families of individuals with high total cholesterol and low HDL levels, and significantly lower IHD prevalence in families of young adults with high total cholesterol and high HDL levels. Among individuals with low total cholesterol, lower family history scores were found in those with lower HDL levels.

References

Feb 5, 1976·The New England Journal of Medicine·G G RhoadsA Kagan
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Jun 1, 1966·Circulation·S DeutscherM O Kjelsberg
Jul 1, 1967·Journal of Chronic Diseases·J TruettW Kannel
Feb 1, 1982·American Journal of Public Health·C H PatrickJ A Brody

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Citations

Jun 23, 1998·Journal of Clinical Epidemiology·S L KardiaC F Sing
Nov 5, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·O Kalter-LeiboviciU Goldbourt
Nov 30, 2006·Statistics in Medicine·H MuradL S Freedman
Jan 1, 1986·Genetic Epidemiology·T ReedL H Kuller
Jul 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C CruiseP Houston
Jan 1, 1993·American Journal of Human Biology : the Official Journal of the Human Biology Council·Patricia Peyser Moll
Apr 9, 1987·The New England Journal of Medicine
Jan 17, 2021·Asian Journal of Psychiatry·Furkhan AliSanjeev Jain

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