PMID: 11899361Mar 20, 2002Paper

Young age as an adverse prognostic factor in premenopausal women with operable breast cancer

Clinical Breast Cancer
R R LoveThomas C Havighurst

Abstract

Data regarding young age as an independent prognostic factor have been conflicting. We investigated this variable in 696 premenopausal Vietnamese and Chinese women with operable breast cancer who participated in a clinical trial of adjuvant surgical oophorectomy and tamoxifen. Tumor size and axillary lymph node status did not vary with age. Women < 35 years had a greater fraction of histologic grade III tumors (P = 0.06), and in the two thirds of patients with available data, in women < 35 years, there was a lower percentage of estrogen- and progesterone receptor-positive tumors and a higher percentage of HER2/neu-positive tumors (P > 0.14 for each group). In univariate analyses, compared to women > or = 45 years, women < 35 years and 35-39 years were at greater risk for death (P = 0.002 and P = 0.023, respectively), and compared to women > or = 40, women < 40 were at greater risk of death (P = 0.002). Multivariate analyses supported a conclusion that younger age was an independent adverse prognostic factor for survival (P = 0.005, age as a continuous variable). Kaplan-Meier analyses in all patients and in oophorectomy and tamoxifen-treated patients, but not in observation-only patients, showed statistically significant poorer ...Continue Reading

Citations

Jul 9, 2003·Breast Cancer Research and Treatment·Richard R LoveThomas C Havighurst
Jul 31, 2004·Cancer Control : Journal of the Moffitt Cancer Center·Natalie G CoburnBlake Cady
Sep 28, 2007·Annals of Surgical Oncology·Jeong Kyeung KimSei Hyun Ahn
Sep 10, 2015·BioMed Research International·Minna K LeeHelena R Chang
Jun 12, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ann H PartridgeRichard D Gelber
Jan 7, 2017·Annals of Surgical Oncology·Morgan K RichardsSara H Javid
Sep 14, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne Hamilton
Apr 19, 2015·World Journal of Surgical Oncology·Jasmine BrandtJonas Manjer
Nov 8, 2006·British Journal of Cancer·J K ChanG S Leiserowitz
Sep 25, 2010·Journal of American College Health : J of ACH·Kanayo Umeh, Leonnie Jones
Apr 12, 2012·Archives of Gynecology and Obstetrics·Constanze Banz-JansenDorothea Fischer
Jun 5, 2010·American Journal of Clinical Oncology·Shani Paluch-ShimonBella Kaufman
Apr 28, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dan TongRobert Zeillinger

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