Young and Restless: Expansion of Donor-Origin Mutant HSCs after Transplantation

Cell Stem Cell
David P Steensma

Abstract

In a study of young adults chosen as unrelated hematopoietic stem cell donors for patients with hematological malignancies, leukemia-associated mutations were detectable in cells from 44% of donors. Donor-origin mutant clones engrafted in recipients and expanded during the first 100 days after transplant, but donor-derived leukemia was not observed.

References

Jul 24, 2012·Cell·John S WelchRichard K Wilson
Jun 22, 2017·The New England Journal of Medicine·Siddhartha JaiswalBenjamin L Ebert
Jul 11, 2018·Nature·Sagi AbelsonLiran I Shlush
Nov 8, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mareike FrickFrederik Damm
Nov 2, 2019·Science·Siddhartha Jaiswal, Benjamin L Ebert

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