Young colorectal cancer patients often present too late

International Journal of Colorectal Disease
Jia-Hao LawKer-Kan Tan

Abstract

Current screening and health education strategies on colorectal cancer (CRC) remain focused on individuals >50 years old. However, CRC in young adults is not uncommon. This paper aims to explore how CRC presents in young adults and their clinical outcomes. All patients aged <50 years diagnosed with CRC from January 2007 to December 2015 were reviewed. Patient demographics, clinical symptoms, and outcomes of treatment were collected. Of 1367 patients diagnosed with CRC, 154 (11.6%) were aged <50 years. The median age of diagnosis was 45 years (range, 19-49). The majority (61%) of the patients presented acutely via the emergency department and the three most common presenting symptoms were abdominal pain (n = 94; 61.0%), change in bowel habits (n = 74; 48.1%), and per rectal bleeding (n = 69; 44.8%). Most of the primary cancers were left sided (n = 122, 79.2%) in location and 33 (21.4%) patients had metastatic disease on presentation. 138 (89.6%) patients were treated with curative intent, including 17 (51.5%) with metastatic disease on presentation. There were 31 (22.5%) patients who developed disease recurrence at a median duration of 10.0 (range, 0.5-94.0) months. The younger group (<45 years old) were more likely to present a...Continue Reading

References

Jul 9, 2004·BMJ : British Medical Journal·UNKNOWN UK Colorectal Cancer Screening Pilot Group
Jan 6, 2006·The Cancer Journal·Rosemary Yancik
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Oct 20, 2009·Seminars in Oncology·Kevin ZbukMichael P La Quaglia
Feb 13, 2010·World Journal of Surgery·Yik-Hong HoRussel Stitz
Sep 17, 2013·World Journal of Gastroenterology : WJG·Elizabeth A MyersRichard L Whelan
Jan 8, 2014·Mayo Clinic Proceedings·Dennis J AhnenY Nancy You
Jan 11, 2014·International Journal of Colorectal Disease·João Batista de SousaPaulo Gonçalves de Oliveira
Feb 11, 2014·Diseases of the Colon and Rectum·Scott R SteeleMarlin W Causey
Dec 4, 2014·World Journal of Surgical Oncology·Andrew McKayDonna Turner
Aug 25, 2015·Surgery·Ramzi AmriDavid L Berger
Sep 12, 2015·International Journal of Colorectal Disease·Jennifer LiangJames Church

❮ Previous
Next ❯

Citations

Oct 9, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C C AneleA Latchford
Dec 29, 2020·ANZ Journal of Surgery·Ashray RajagopalanWilliam Teoh
Mar 2, 2021·World Journal of Gastrointestinal Surgery·Matteo MuellerMatthias Turina

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved