Young HIV-infected children and their adult caregivers prefer tablets to syrup antiretroviral medications in Africa.

PloS One
Patricia Nahirya-NtegeARROW Trial Team

Abstract

Provision of anti-retroviral therapy (ART) for HIV-infected children is complicated using syrup formulations, which are costlier than tablets, harder to transport and store and difficult for health-workers to prescribe and caregivers to administer. Dispersible/crushable tablets may be more appropriate. We studied the acceptability of syrups and scored tablets among young children who used both in the AntiRetroviral Research fOr Watoto (ARROW) trial. ARROW is an ongoing randomized trial of paediatric ART monitoring and treatment strategies in 1206 children in Uganda and Zimbabwe. 405 children initially received syrups of combination ART including Nevirapine, Zidovudine, Abacavir and Lamivudine before changing, when reaching the 12-<15 kg weightband, to scored adult-dose tablets prescribed according to WHO weightband tables. Caregiver expectations and experiences were collected in questionnaires at their last visit on syrups and after 8 and 24 weeks on tablets. Questionnaires were completed by caregivers of 267 children (median age 2.9 years (IQR 2.5, 3.4)). At last visit on syrups, 79% caregivers reported problems with syrups, mostly related to number, weight, transportation and conspicuousness of bottles. Difficulties taking ta...Continue Reading

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Citations

Mar 9, 2013·Annals of Biomedical Engineering·Garrett J SpiegelRebecca Richards-Kortum
May 25, 2013·The Journal of Infectious Diseases·Felicity FitzgeraldDiana Gibb
Jun 12, 2013·Current HIV/AIDS Reports·Francisco J Ramos-Gomez, Morenike Oluwatoyin Folayan
Apr 19, 2013·AIDS·Quirine FillekesUNKNOWN CHAPAS-1 trial team
Feb 4, 2014·Drug Development and Industrial Pharmacy·Areeg Anwer AliDaud Baraka Abdallah
Jun 1, 2014·Expert Opinion on Drug Metabolism & Toxicology·Diane E T BastiaansDavid M Burger
Jul 15, 2016·AIDS Research and Treatment·Adrienne F SchlatterRachel C Vreeman
Aug 16, 2016·The Journal of Pharmacy and Pharmacology·Punam MistryUNKNOWN SPaeDD-UK project (Smart Paediatric Drug Development - UK)
Apr 12, 2016·AIDS·Victor MusiimeUNKNOWN ARROW Trial Team
Aug 4, 2020·Bulletin of the World Health Organization·Grace LiMike Sharland
Dec 15, 2018·Journal of the International AIDS Society·Briony PasipanodyaTsitsi Apollo

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Software Mentioned

ARROW
Stata

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