Young women with advanced aortoiliac occlusive disease: new insights

Annals of Vascular Surgery
P J GagneJ F Eidt

Abstract

We identified a group of 24 young (less than 50 years of age) women with isolated, premature atherosclerotic aortoiliac occlusive disease and attempted to identify distinguishing hemostatic characteristics. Most of these patients (62%) presented with acute thromboembolic events (blue toe syndrome, n = 6; macroemboli, n = 6; or aortoiliac thrombosis, n = 3). Aortoiliac reconstruction (aortoiliac endarterectomy, n = 10, aortobifurcation bypass grafts, n = 6; and percutaneous angioplasty, n = 4) was complicated by early thrombosis in 6 of 20 cases (30%), (1 of 10 endarterectomies, 4 of 6 bypass grafts, and 1 of 4 angioplasties). Fresh thrombus overlying an atherosclerotic plaque was a common finding at surgery. This observation and the relatively high incidence of thromboembolic events led us to hypothesize that a characteristic hemostatic profile might underlie the remarkably similar clinical presentations of these women. Levels of antiphospholipid antibodies (anticardiolipin antibodies and lupus anticoagulant), plasminogen activator inhibitor-1, fibrinogen, antithrombin III, protein C, protein S, plasminogen, prothrombin fragment F1 + 2, and D-dimer were determined for these young women and for 21 age-matched white female contro...Continue Reading

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Citations

Nov 24, 2011·Interactive Cardiovascular and Thoracic Surgery·Federico BucciPhilippe Plagnol
Mar 24, 1998·Journal of Vascular Surgery·D B SchneiderR J Stoney
Oct 16, 2003·Journal of Vascular Surgery·Maurice A A J van den BoschYolanda van der Graaf
Jul 31, 1998·Journal of Vascular Surgery·J L BallardJ D Killeen
Jul 20, 2004·Angiology·José Maria Pereira de GodoyDorotéia R S Souza
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·M A A J Van Den BoschY Van Der Graaf
Apr 25, 2003·Vascular Medicine·Lezek MaslowskiWaldemar E Wysokinski
Oct 17, 2020·Seminars in Arthritis and Rheumatism·Mira MerashliPaul Rj Ames

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