Younger gestational age is associated with increased risk of adverse neurodevelopmental outcome during infancy in congenital diaphragmatic hernia

Journal of Pediatric Surgery
Enrico DanzerHolly L Hedrick

Abstract

The purpose of the study was to investigate the impact of gestational age (GA) on short-term neurodevelopmental (ND) outcomes in congenital diaphragmatic hernia survivors. Between 6/2004 and 2/2013, 135 consecutive CDH patients underwent ND assessment using the Bayley Scales of Infant Development-III at a median follow-up age of 13months (range, 5-36). ND delay was defined by a score of ≤85 in any of the composite scales. Severe impairment was defined as a score of ≤69 in at least one domain. The effect of GA was evaluated as continuous and categorical variables. GA at delivery was grouped into full term (39-41weeks), near term (37-38), late preterm (34-36), and preterm (24-33). Median GA at delivery was 38weeks (range, 24-41). Fifty (37%) patients were delivered full term, 59 (44%) near term, 16 (12%) late preterm, and 10 (7%) preterm. CDH children born before 39weeks' gestation were more likely to score below average (P=0.005) with corrected age for at least one composite score compared to full term peers. Cognitive (P=0.06) and language (P=0.08) scores tended to be lower in the near-term and late-preterm group compared to full-term CDH infants. Patients born near term and late preterm had significantly lower motor composite ...Continue Reading

References

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Dec 7, 2007·Pediatrics·William A EngleUNKNOWN Committee on Fetus and Newborn, American Academy of Pediatrics
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Jun 7, 2011·Early Human Development·Enrico Danzer, Holly L Hedrick
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May 11, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·E DanzerH L Hedrick
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Sep 26, 2014·World Journal of Clinical Pediatrics·Enrico Danzer, Stephen S Kim
Dec 3, 2014·Seminars in Fetal & Neonatal Medicine·Enrico Danzer, Holly L Hedrick

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Citations

Aug 28, 2016·The American Journal of Pathology·Patricia K DonahoeFrances A High
Jan 6, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Enrico DanzerHolly L Hedrick
Jun 4, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Anna-May LongUNKNOWN BAPS-CASS
Oct 19, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Allison M PelusoHany Aly
Jul 2, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·H BouchghoulA Benachi
Oct 29, 2017·Journal of Pediatric Surgery·Ryan M AntielHolly L Hedrick

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