Younger patients with primary Sjögren's syndrome are more likely to have salivary IgG anti-muscarinic acetylcholine receptor type 3 antibodies

Clinical Rheumatology
K JayakanthanDebashish Danda

Abstract

Acetylcholine type 3 receptor (M3R) is recognized as an autoantigen in primary Sjögren's syndrome (pSS). Assay of anti-M3R antibody levels in serum is fraught with low sensitivity for diagnosis of pSS. Salivary assay is more likely to improve the diagnostic accuracy. Patients with pSS classified either by the American European Consensus Group (AECG) or American college of Rheumatology (ACR) criteria, attending rheumatology clinic between October 2014 and July 2015 were included. Hospital staff and lupus patients constituted healthy and disease controls, respectively. Evaluation of pSS included clinical evaluation, laboratory tests, ESSDAI and ESSPRI scoring. Unstimulated saliva was collected by the spitting method. Salivary IgG antibody against M3R (anti-M3R) was quantified by indirect ELISA. In this study, 43 patients with pSS, 34 with lupus and 42 healthy controls were recruited. The frequency of anti-M3R antibody levels was 55.81, 17.64 and 7 % for pSS, lupus and healthy controls, respectively. Area under the Receiver Operator Characteristic was 0.7791 (95 % CI,, 0.67-0.87). Sensitivity and specificity of the assay for diagnosis of pSS were 44.19 and 88.16 %, respectively. Salivary anti-M3R IgG antibody positivity was associ...Continue Reading

References

Sep 1, 1968·Journal of Clinical Pathology·D M Chisholm, D K Mason
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Jul 12, 2011·Journal of Clinical Immunology·Clothilde MartelAnne Laure Fauchais
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May 12, 2012·Journal of Autoimmunity·Vasiliki-Kalliopi Bournia, Panayiotis G Vlachoyiannopoulos
Jul 15, 2015·The Open Rheumatology Journal·Pulukool SandhyaDebashish Danda

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Citations

Mar 16, 2018·Rheumatology International·Santosh Kumar MandalDebashish Danda

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