Young's moduli of surface-bound liposomes by atomic force microscopy force measurements

Langmuir : the ACS Journal of Surfaces and Colloids
Heïdi Brochu, Patrick Vermette

Abstract

Mechanical properties of layers of intact liposomes attached by specific interactions on solid surfaces were studied by atomic force microscopy (AFM) force measurements. Force-distance measurements using colloidal probe tips were obtained over liposome layers and used to calculate Young's moduli by using the Hertz contact theory. A classical Hertz model and a modified Hertz one have been used to extract Young's moduli from AFM force curves. The modified model, proposed by Dimitriadis, is correcting for the finite sample thickness since Hertz's classical model is assuming that the sample is infinitely thick. Values for Young's moduli of 40 and 8 kPa have been obtained using the Hertz model for one and three layers of intact liposomes, respectively. Young's moduli of approximately 3 kPa have been obtained using the corrected Hertz model for both one and three layers of surface-bound liposomes. Compression work performed by the colloidal probe to compress these liposome layers has also been calculated.

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Citations

Jul 22, 2014·Micron : the International Research and Review Journal for Microscopy·Jiang PiJiye Cai
Oct 19, 2010·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Qian ChenYun-Long Pan
Mar 31, 2009·Expert Opinion on Drug Delivery·Ellas SpyratouCostas Demetzos
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Oct 5, 2010·Micron : the International Research and Review Journal for Microscopy·Xiaofang CaiFeicheng Huang
Jan 12, 2010·Micron : the International Research and Review Journal for Microscopy·Xiaofang CaiFeicheng Huang
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Aug 12, 2008·Experimental Cell Research·Julie A ChouinardPatrick Vermette
Jul 25, 2019·Physical Review. E·Glauber T SilvaBruce W Drinkwater
Jun 13, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Anna TarasovaLaurence Meagher
Jun 20, 2021·Colloids and Surfaces. B, Biointerfaces·Raul Diaz-SalmeronKawthar Bouchemal
May 6, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Oumaima Et-ThakafyFanny Guyomarc'h

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