Abstract
Adolescents with type 1 diabetes (T1D) have difficulty obtaining optimal glucose control, which may relate to insulin resistance (IR), especially during puberty. Moreover, IR increases the risk for cardiovascular disease, the leading cause of death in T1D. However, the tissue specificity of IR in adolescents with T1D has not been fully phenotyped. To assess adipose, hepatic, and peripheral insulin sensitivity in adolescents with and without T1D. Thirty-five youth with T1D [median age, 16 (first and third quartiles, 14, 17) years; 53% female; median body mass index (BMI) percentile, 82nd (55th, 96th); late puberty; median hemoglobin A1c, 8.3% (7.3%, 9.4%)] and 22 nondiabetic youth of similar age, BMI, pubertal stage, and level of habitual physical activity were enrolled. Insulin action was measured with a four-phase hyperinsulinemic euglycemic clamp (basal and 10, 16, and 80 mU/m2/min) with glucose and glycerol isotope tracers. Adolescents with T1D had a significantly higher rate of lipolysis (P < 0.0001) and endogenous glucose production (P < 0.001) and lower peripheral glucose uptake (glucose rate of disappearance, 6.9 ± 2.9 mg/kg/min for patients with T1D vs 11.3 ± 3.3 for controls; P < 0.0001) during hyperinsulinemia compare...Continue Reading
References
Aug 15, 1992·Analytical Biochemistry·C D GilkerD E Matthews
Jun 1, 1988·Acta Endocrinologica·M KollindP E Lins
Jan 1, 1974·The Journal of Clinical Investigation·J E LiljenquistG W Liddle
Mar 1, 1984·Diabetes·J S DormanA L Drash
Mar 1, 1993·Metabolism: Clinical and Experimental·S ArslanianS C Kalhan
Jun 15, 1996·The Journal of Clinical Investigation·M RodenG I Shulman
Jan 1, 1997·Medicine and Science in Sports and Exercise·A T WestonR R Pate
Aug 23, 2000·The Journal of Clinical Investigation·H N Ginsberg
Dec 25, 2002·Journal of Pediatric Gastroenterology and Nutrition·Mark H FishbeinJennifer Chalekson
Apr 30, 2003·Diabetes Care·Trevor J OrchardDorothy J Becker
May 30, 2003·Diabetologia·S P LaingC C Patterson
Sep 27, 2003·Lancet·Ram WeissSonia Caprio
Oct 28, 2003·Diabetes·Dana DabeleaUNKNOWN Coronary Artery Calcification in Type 1 Diabetes Study
Nov 18, 2005·The Journal of Clinical Endocrinology and Metabolism·Céline DruetClaire Levy-Marchal
Feb 7, 2007·Atherosclerosis·Jean-Paul AlbertiniPaul Valensi
Jul 9, 2009·The Journal of Clinical Endocrinology and Metabolism·Kristen J NadeauJudith G Regensteiner
Nov 17, 2009·The Journal of Clinical Endocrinology and Metabolism·Kristen J NadeauJane E B Reusch
Oct 28, 2010·Diabetes·Irene E SchauerMarian Rewers
May 6, 2011·Diabetes Care·Paolo PozzilliRaffaella Buzzetti
Jan 27, 2012·The Journal of Clinical Endocrinology and Metabolism·Rocio I PereiraDavid M Maahs
Mar 1, 2012·The Journal of Clinical Endocrinology and Metabolism·Bryan C BergmanMarian Rewers
Aug 28, 2012·The Journal of Pediatrics·Brian J SpechtDavid M Maahs
Nov 9, 2012·Current Diabetes Reports·Melanie Cree-GreenKristen J Nadeau
Nov 15, 2012·The Journal of Clinical Endocrinology and Metabolism·Bryan C BergmanMarian Rewers
Aug 27, 2014·Diabetes·Melanie Cree-GreenKristen J Nadeau
Feb 26, 2015·American Journal of Physiology. Endocrinology and Metabolism·Melanie Cree-GreenKristen J Nadeau
Mar 5, 2015·Journal of Diabetes and Its Complications·Amy S ShahDana Dabelea
Jun 18, 2015·Pediatric Diabetes·Melanie Cree-GreenKristen J Nadeau
Jul 15, 2015·The Journal of Pediatrics·Stephanie N DuBoseUNKNOWN Type 1 Diabetes Exchange Clinic Network and Diabetes Prospective Follow-up Registry
Nov 4, 2016·Pediatric Diabetes·Fida Bacha, Sara Klinepeter Bartz
Dec 31, 2015·American Journal of Physiology. Endocrinology and Metabolism·Laura PyleMelanie Cree-Green
Mar 20, 2016·Diabetes·David C PolidoriAnne E Sumner
May 3, 2016·Journal of Diabetes and Its Complications·Petter BjornstadKristen J Nadeau
Sep 18, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Amalia GastaldelliPatricia Iozzo
Oct 14, 2016·Diabetologia·Thomas S VossNiels Møller
Nov 3, 2016·Obesity·Melanie Cree-GreenKristen J Nadeau
Citations
Oct 18, 2018·Current Diabetes Reports·Petter Bjornstad, Robert H Eckel
Dec 19, 2018·American Journal of Physiology. Endocrinology and Metabolism·Melanie Cree-GreenKristen J Nadeau
Jan 18, 2019·Exercise and Sport Sciences Reviews·Cynthia M F MonacoThomas J Hawke
Oct 30, 2019·Obesity·Melanie Cree-GreenKristen J Nadeau
Mar 3, 2020·Diabetes Technology & Therapeutics·Melissa J SchoelwerMarc D Breton
Jun 11, 2020·Current Opinion in Pediatrics·Elżbieta Niechciał, M Loredana Marcovecchio
Sep 15, 2020·Diabetologia·Katherine V WilliamsTrevor J Orchard
Apr 3, 2019·The Journal of Clinical Endocrinology and Metabolism·Melanie Cree-GreenKristen J Nadeau
Sep 18, 2020·Pediatric Diabetes·Elena FornariClaudio Maffeis
Apr 22, 2020·Diabetes·Justin M GregoryDaniel J Moore
Aug 2, 2020·Diabetes·Carissa VinovskisPetter Bjornstad
Apr 9, 2021·Frontiers in Endocrinology·Christine A MarchIngrid M Libman
Jun 3, 2021·Diabetes/metabolism Research and Reviews·Arianna PetrelliMelania Manco
Jun 18, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Valeria CalcaterraGianvincenzo Zuccotti
Jul 20, 2021·Endocrinology, Diabetes & Metabolism·Falastin SalamiUNKNOWN TEDDY Study Group
Aug 28, 2021·Children·Valeria CalcaterraChiara Mameli
Sep 7, 2021·Hormones : International Journal of Endocrinology and Metabolism·Alexandra EfthymiadouDionisios Chrysis
May 17, 2019·Diabetes·Justin M GregoryDaniel J Moore