Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance.

The Journal of Clinical Endocrinology and Metabolism
Melanie Cree-GreenKristen J Nadeau

Abstract

Adolescents with type 1 diabetes (T1D) have difficulty obtaining optimal glucose control, which may relate to insulin resistance (IR), especially during puberty. Moreover, IR increases the risk for cardiovascular disease, the leading cause of death in T1D. However, the tissue specificity of IR in adolescents with T1D has not been fully phenotyped. To assess adipose, hepatic, and peripheral insulin sensitivity in adolescents with and without T1D. Thirty-five youth with T1D [median age, 16 (first and third quartiles, 14, 17) years; 53% female; median body mass index (BMI) percentile, 82nd (55th, 96th); late puberty; median hemoglobin A1c, 8.3% (7.3%, 9.4%)] and 22 nondiabetic youth of similar age, BMI, pubertal stage, and level of habitual physical activity were enrolled. Insulin action was measured with a four-phase hyperinsulinemic euglycemic clamp (basal and 10, 16, and 80 mU/m2/min) with glucose and glycerol isotope tracers. Adolescents with T1D had a significantly higher rate of lipolysis (P < 0.0001) and endogenous glucose production (P < 0.001) and lower peripheral glucose uptake (glucose rate of disappearance, 6.9 ± 2.9 mg/kg/min for patients with T1D vs 11.3 ± 3.3 for controls; P < 0.0001) during hyperinsulinemia compare...Continue Reading

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Citations

Oct 18, 2018·Current Diabetes Reports·Petter Bjornstad, Robert H Eckel
Dec 19, 2018·American Journal of Physiology. Endocrinology and Metabolism·Melanie Cree-GreenKristen J Nadeau
Jan 18, 2019·Exercise and Sport Sciences Reviews·Cynthia M F MonacoThomas J Hawke
Jun 11, 2020·Current Opinion in Pediatrics·Elżbieta Niechciał, M Loredana Marcovecchio
Sep 15, 2020·Diabetologia·Katherine V WilliamsTrevor J Orchard
Apr 3, 2019·The Journal of Clinical Endocrinology and Metabolism·Melanie Cree-GreenKristen J Nadeau
Aug 2, 2020·Diabetes·Carissa VinovskisPetter Bjornstad
Apr 9, 2021·Frontiers in Endocrinology·Christine A MarchIngrid M Libman
Jun 3, 2021·Diabetes/metabolism Research and Reviews·Arianna PetrelliMelania Manco
Jun 18, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Valeria CalcaterraGianvincenzo Zuccotti
Jul 20, 2021·Endocrinology, Diabetes & Metabolism·Falastin SalamiUNKNOWN TEDDY Study Group
Sep 7, 2021·Hormones : International Journal of Endocrinology and Metabolism·Alexandra EfthymiadouDionisios Chrysis

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