You've got to be kindlin!

Blood
Scott I Simon

Abstract

In this issue of Blood, Liao et al report that kindlin-2 is necessary for angiogenic sprouting in vitro and for developmental and tumor angiogenesis in vivo. The process of blood vessel sprouting is known to involve the αVβ3 vitronectin integrin on endothelium. Kindlin-2 linkage to the C-terminal tail of β3 completed the outside-in circuit necessary for integrin signaling that is critical for navigation of new vessel sprouts.

References

Nov 25, 2003·The Journal of Biological Chemistry·Susanne KloekerMary C Beckerle
Feb 19, 2008·Nature Medicine·Markus MoserReinhard Fässler
May 17, 2008·Genes & Development·Eloi MontanezReinhard Fässler
Nov 14, 2008·Blood·Ararat J AbloogluSanford J Shattil
Jun 26, 2009·Current Opinion in Hematology·Edward F PlowTatiana Byzova
Nov 18, 2014·Biochemical Society Transactions·Samuel J AtkinsonStephen D Robinson

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Citations

Oct 2, 2020·Experimental Hematology & Oncology·Luhui LinXudong Ma

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