YRNAs overexpression and potential implications in allergy

The World Allergy Organization Journal
María Isidoro-GarcíaIgnacio Dávila

Abstract

Small non-coding RNAs (snRNAs) develop important functions related to epigenetic regulation. YRNAs are snRNAs involved in the initiation of DNA replication and RNA stability that regulate gene expression. They have been related to autoimmune, cancer and inflammatory diseases but never before to allergy. In this work we described for the first time in allergic patients the differential expression profile of YRNAs, their regulatory mechanisms and their potential as new diagnostic and therapeutic targets. From a previous whole RNAseq study in B cells of allergic patients, differential expression profiles of coding and non-coding transcripts were obtained. To select the most differentially expressed non coding transcripts, fold change and p-values were analyzed. A validation of the expression differences detected was developed in an independent cohort of 304 individuals, 208 allergic patients and 96 controls by using qPCR. Potential binding and retrotransponibility capacity were characterized by in silico structural analysis. Using a novel bioinformatics approach, RNA targets identification, functional enrichment and network analyses were performed. We found that almost 70% of overexpressed non-coding transcripts in allergic patien...Continue Reading

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Methods Mentioned

BETA
RNAseq
PCR
nucleotide Exchange

Software Mentioned

BLAST
BLAT
RT Analyzer
DAVID
Primer
RNAseq
Clustal W2
topFun
DESeq package
Gene MANIA

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