PMID: 3771152Oct 1, 1986Paper

Ytterbium-DTPA. A potential intravascular contrast agent

Investigative Radiology
E Unger, F Gutierrez

Abstract

Ytterbium-DTPA was evaluated as a potential intravascular contrast agent. Ytterbium-DTPA was synthesized from ytterbium oxide and diethylene triamine penta-acetic acid (DTPA). CT scans of increasing concentrations of ytterbium and iodine showed that at 125 kVp, ytterbium was denser than an equal concentration of iodine. The LD50 of intravenous ytterbium-DTPA was 10 mM/kg (1.73 g ytterbium/kg) in rats. In enhanced CT scans and pulmonary angiography in dogs, ytterbium was visibly denser than iodine, and CT Hounsfield units showed greater enhancement of the aorta and inferior vena cava with ytterbium. The animals showed no sign of acute or delayed toxicity. Ytterbium-DTPA deserves further evaluation as a contrast agent for high kVp techniques.

Citations

Sep 11, 2012·Physical Chemistry Chemical Physics : PCCP·Hongyu ChenJeffrey N Anker
Jan 29, 2014·Contrast Media & Molecular Imaging·Dipanjan PanGregory M Lanza
Mar 12, 2013·IEEE Transactions on Medical Imaging·Carsten O SchirraRoland Proksa
Apr 22, 2017·Inorganic Chemistry·Markus BergerKaspar Hegetschweiler
Dec 26, 2001·Chemical Reviews·S B Yu, A D Watson

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