Yttrium-90 radioembolization for unresectable metastatic neuroendocrine liver tumor: A systematic review

European Journal of Radiology
Zhongzhi Jia, Weiping Wang

Abstract

To evaluate the value of yttrium-90 (90Y) microspheres in the management of unresectable liver metastases secondary to neuroendocrine tumors (NETs). PubMed, EMBASE, the Cochrane Database of Systematic Reviews, and the "gray" literature (Google Scholar) were searched for all studies related to 90Y therapy for unresectable liver metastases of NETs. A total of 11 studies and 7 abstracts involving 870 patients were included in the final analysis. In 11 of these studies, 19.8% (77/388) of patients had undergone transarterial bland embolization (TABE) or transarterial chemoembolization (TACE) before 90Y therapy. The median disease control rate among all patients was 86% at 3 months after 90Y therapy. The median survival was 28 months, with 1-, 2-, and 3-year survival rates of 72.5%, 57%, and 45%, respectively. The median survival values for patients who received resin- and glass-based 90Y treatment were 27.6 and 31.7 months, respectively. The survival values for patients with carcinoid, pancreatic, and unclassified origin of NETs were 56, 31, and 28 months, respectively; the survival values for patients with grade I, II, and III NETs were 71, 56, and 28 months, respectively. Carcinoid syndrome was reported in 52.4% (55/105) of patien...Continue Reading

Citations

Jul 17, 2018·World Journal of Surgical Oncology·Giuseppe NigriGiovanni Ramacciato
Mar 20, 2019·World Journal of Gastroenterology : WJG·Dominique Svm ClementJohn K Ramage
May 25, 2020·Current Treatment Options in Oncology·Donna D'SouzaShamar Young
Jul 21, 2020·World Journal of Gastroenterology : WJG·Sergio SartoriPaola Tombesi
Oct 18, 2019·ACG Case Reports Journal·Derek J EstesDaniel A Sussman
Sep 30, 2020·Physics in Medicine and Biology·Lucrezia AuditoreSilvano Gnesin
Mar 2, 2021·British Journal of Hospital Medicine·Emma Preston, Nadeem Shaida
Nov 28, 2020·Physics in Medicine and Biology·Lucrezia AuditoreSilvano Gnesin
Apr 5, 2021·Surgery·Thomas J O'MalleyVakhtang Tchantchaleishvili
Mar 17, 2020·Neuroendocrinology·Rahul KanabarAngela Lamarca

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