Yttrium (amidate) complexes for catalytic C-N bond formation. Rapid, room temperature amidation of aldehydes

Dalton Transactions : an International Journal of Inorganic Chemistry
Jaclyn A Thomson, Laurel L Schafer

Abstract

Yttrium (amidate) precatalysts are highly active for the mild amidation of aldehydes with amines. Reactions occur at room temperature within 5 min in up to 98% isolated yield. These rare-earth systems are effective for this transformation in the absence of supplementary heat, light, base, or oxidants. The reaction proceeds with functionalized amines and/or aldehydes. A comparison of various amidate precatalysts in combination with reaction monitoring suggests that the targeted amide products formed during the reaction promote the formation of alternative catalytically active amidate species in situ.

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Citations

May 27, 2016·The Journal of Organic Chemistry·Giorgos N Papadopoulos, Christoforos G Kokotos
Jan 29, 2013·The Journal of Organic Chemistry·Narsimha Mamidi, Debasis Manna
Apr 21, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Chao GongYingming Yao
Feb 26, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Bei ZhaoYingming Yao
Jun 9, 2015·Organic & Biomolecular Chemistry·Hao XieGuo-Jun Deng
Sep 21, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Philippa R PayneLaurel L Schafer
Dec 18, 2013·Angewandte Chemie·Shuai ShiA Stephen K Hashmi

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